The microenvironment encompasses all components of a tumor other than the cancer cells
themselves. It is highly heterogenous, comprising a cellular component that includes …

Stromal cells of the tumor microenvironment have been shown to play important roles in
both supporting and limiting cancer growth. The altered phenotype of tumor-associated …

Simple Summary In this review article, we will deepen the topic of cancer cell
communication with the surrounding non-cancerous cells. In particular, the non-mutational …

Activated tumor stroma participates in tumor cell growth, invasion, and metastasis. Normal
fibroblasts and cancer-associated fibroblasts (CAFs) have been shown to display distinct …

Increasing evidence shows that the interaction between neoplastic cells and the
surrounding stroma is a critical factor in solid tumor growth. The tumor stroma is made up of …

Primary tumor growth induces host tissue responses that are believed to support and
promote tumor progression. Identification of the molecular characteristics of the tumor …

Lest we forget, within every higher organism, there are literally billions of cells with identical
genetic information that serve as constituents of the different tissues and organs. Given that …

In the past century, gradual but sustained advances in our understanding of the molecular
mechanisms involved in the growth and invasive properties of cancer cells have led to better …

Recent advances in tumor biology have revealed that a detailed analysis of the complex
interactions of tumor cells with their adjacent microenvironment (tumor stroma) is mandatory …

Simple Summary Normal epithelial cells in our organs are surrounded by stroma, which is
an ecosystem made up of a variety of cells and proteins that support their intended functions …