Normal tissue homeostasis is maintained by dynamic interactions between epithelial cells
and their microenvironment. As tissue becomes cancerous, there are reciprocal interactions …

The restricted view of tumour progression as a multistep process defined by the
accumulation of mutations in cancer cells has largely ignored the substantial contribution of …

The tumor microenvironment is considered pro-oncogenic for reasons that, among others,
involve the stimulation of cancer cell growth. However, little is known regarding how the …

Introduction 3. Roles of the stroma in immune escape of tumor and stem cells 4. Specialized
stromal cells within tumor microenvironment and stem cell niches regulate survival …

Solid tumors are organ-like entities. In addition to neoplastic cells, they consist of non-
transformed host stromal cells such as endothelial cells, fibroblasts and inflammatory cells …

The tumor-associated stroma has been shown to play a significant role in cancer formation.
Paracrine signaling interactions between epithelial tumor cells and stromal cells are a key …

The major cellular components of tumor microenvironment, referred to as the cancer stroma,
are composed of cancer-associated fibroblasts that support tumor epithelial growth, invasion …

Mammary stromal tissue has a major role in the control and regulation of physiological
processes in the breast. Recently, the function of stroma in supporting the tumourigenic …

Cancers are a complex set of proliferative diseases that arise in most cases through multi-
step pathways involving an accumulation of genetic and epigenetic changes. These steps …

The tumor stroma is comprised of extracellular matrix, non-malignant cells, and the signaling
molecules they produce. It is an integral and vital component of primary tumors that together …