Tumors arise from cells that have sustained genetic mutations resulting in deregulation of
several of their normal growth-controlling mechanisms. Much of the research concerning the …

Successful establishment of a tumour relies on a cascade of interactions between cancer
cells and stromal cells within an evolving microenvironment. Both immune and nonimmune …

Stromal cells are essential for the progression of many cancers including ovarian tumors.
Stromal cell-epithelial cell interactions are important for tumor development, growth …

From the morphogenetic movements of the three germ layers during development to the
reactive stromal microenvironment in cancer, tissue interactions are vital to maintaining …

All cancers depend on stroma for support of growth. Leukemias, solid tumors, cancer cells
causing effusions, metastases as well as micro-disseminated cancer cells release factors …

The stroma in human carcinomas consists of extracellular matrix and various types of non-
carcinoma cells, mainly leukocytes, endothelial cells, fibroblasts, myofibroblasts and bone …

The microenvironment in which cancer arises plays a critical role in tumorigenesis. Although
previously regarded as an innocent bystander, evidence has accumulated over the past 10 …

Studies of epithelial cancers (ie, carcinomas) traditionally focused on transformation of the
epithelium (ie, the cancer cells) and how aberrant signaling within the cancer cells …

Cancer forms specialized microenvironmental niches that promote local invasion and
colonization. Engrafted patient-derived xenografts (PDXs) locally invade and colonize naïve …

Bone marrow mesenchymal stem/stromal cells (BM-MSCs) can infiltrate into tumors and
subsequently evolve into tumor resident MSCs in tumor microenvironment. In this study …