The basement membrane, immune cells, capillaries, fibroblasts and extracellular matrix
(ECM) constitute the tumour stroma, commonly referred to as the 'reactive stroma'. The …

Background The aberrant expression of stromal gene signatures in breast cancer has been
widely studied. However, the association of stromal gene signatures with tumor immunity …

In this issue of Cell, Hill et al.(2005) demonstrate in a mouse model of prostate cancer that
the tumor cells can initiate and promote expansion of stromal fibroblasts that lack the tumor …

It has been well documented that the tumor microenvironment (TME) plays a key role in the
promotion of drug resistance, the support of tumor progression, invasiveness, metastasis …

Background Various cancers have been found to be associated with heterogeneous and
adaptive tumor microenvironments (TMEs) and to be driven by the local TMEs in which they …

Many similarities exist between the stroma at sites of wound repair and reactive stroma in
cancer. Common features include an elevated stromal cell proliferation, altered expression …

It is well accepted that the tumor microenvironment plays a pivotal role in cancer onset,
development, and progression. The majority of clinical interventions are designed to target …

Most research into the biology of carcinoma has focused on the epithelial cells therein; the
inherent assumption has been that the tumour arises from epithelial cells 'gone bad', and …

Conclusions The above summarized findings of this laboratory on tumor-stroma interactions,
together with a growing number of other reports contribute to the accumulating evidence that …

The tumor microenvironment represents a dynamically composed matrix in which tissue-
associated cancer cells are embedded together with a variety of further cell types to form a …