Cancer cells acquire cell-autonomous capacities to undergo limitless proliferation and
survival through the activation of oncogenes and inactivation of tumor suppressor genes …

Tumor tissue is composed of both cancer cells and stromal cells recruited from normal
tissue. These cells include fibroblastic cells, endothelial cells, and cells of hematopoietic …

Although stromal cell signaling has been shown to play a significant role in the progression
of many cancers, relatively little is known about its importance in modulating ovarian cancer …

It has been argued that tumors are not masses of proliferating cells in an isolated
environment, but rather “wounds that do not heal” due to the molecular and cellular …

Tissues and organs harbor a component of supportive mesenchymal stroma. The organ
stroma is vital for normal functioning since it expresses factors instructing growth and …

Abstract The Epithelial-Stromal Interactions Workshop was organized with the purpose of
accelerating progress in understanding the interrelationship between tumor cells and their …

The stroma, which is composed of supporting cells and connective tissue, comprises a large
component of the local microenvironment of many epithelial cell types, and influences …

There is evidence that an aberrant tumour microenvironment (TME) facilitates cancer
development, progression, and responses to treatment. While many of the mechanisms …

A fundamental requirement for cancer initiation is the activation of developmental
programmes by mutant cells. Oncogenic signals often confer an undifferentiated, stem cell …

It is my privilege to be the Guest Editor of this special edition of the Journal of Cellular
Biochemistry Prospects Series focused on the ''Tumor Microenvironment.''It is now well …