Covalent DNA–protein cross-links (DPCs) are toxic DNA lesions that block replication and
require repair by multiple pathways. Whether transcription blockage contributes to the …

DNA–protein crosslinks (DPCs) arise from enzymatic intermediates, metabolism or
chemicals like chemotherapeutics. DPCs are highly cytotoxic as they impede DNA-based …

Restoration of UV-inhibited transcription requires removal of transcription-blocking DNA
lesions by transcription-coupled repair (TCR). In mammals, TCR is dependent on CSA and …

Transcription-coupled DNA repair removes bulky DNA lesions from the genome, and
protects cells against ultraviolet (UV) irradiation. Transcription-coupled DNA repair begins …

Proteins that act on DNA, or are in close proximity to it, can become inadvertently
crosslinked to DNA and form highly toxic lesions, known as DNA-protein crosslinks (DPCs) …

The Cockayne syndrome B (CSB) protein is essential for transcription-coupled DNA repair
(TCR), which is dependent on RNA polymerase II elongation. TCR is required to quickly …

DNA is associated with proteins that are involved in its folding and transaction processes.
When cells are exposed to chemical cross-linking agents or free radical–generating ionizing …

Transcription-coupled repair (TCR) is a mechanism that removes DNA lesions so that genes
can be transcribed correctly. However, the sequence of events that results in a DNA lesion …

DNA–protein crosslinks (DPCs) are highly toxic DNA adducts, but whether dedicated DPC-
repair mechanisms exist was until recently unknown. This has changed with discoveries …

DNA is constantly exposed to a wide array of genotoxic agents, generating a variety of forms
of DNA damage. DNA-protein crosslinks (DPCs)—the covalent linkage of proteins with a …