Early studies of the retinoblastoma gene (RB) have uncovered its critical role as a regulator
of the G 1/S cell cycle phase progression. Surprisingly, genetic approaches in mammals and …

The retinoblastoma tumor suppressor gene, Rb, was the first tumor suppressor identified
and plays a fundamental role in regulation of progression through the cell cycle. This review …

The retinoblastoma (RB) tumour suppressor gene is functionally inactivated in a broad
range of paediatric and adult cancers, and a plethora of cellular functions and partners have …

Since its discovery, the retinoblastoma (RB) tumour-suppressor protein has been a focal
point of cancer research. Accumulating evidence indicates a complex role for RB in cell …

The retinoblastoma (RB) gene is the prototype tumor suppressor gene. It encodes a nuclear
protein that acts as a cell cycle control checkpoint at the G1 phase. Deletion or inactivation of …

The retinoblastoma tumor suppressor (Rb) pathway is mutated in most, if not all human
tumors. In the G0/G1 phase, Rb and its family members p107 and p130 inhibit the E2F family …

The retinoblastoma (Rb) gene is one of the most important genes in cell cycle regulation and
tumorigenesis. Homozygosity for a germ-line Rb mutation results in embryonic lethality and …

The identification of the retinoblastoma gene (rb) has sparked intense inves tigation of tumor
suppressor genes. These genes, like oncogenes, can encode transcriptional regulators …

The retinoblastoma tumour suppressor protein (Rb) has come a long way since its initial
discovery in 1986. Encoded by the first candidate tumour suppressor gene it has emerged a …

The retinoblastoma gene product is an abundant nuclear protein whose 'pocket
domain'mediates numerous protein–protein interactions. A substantial proportion of the RB …