Glycans and glycoproteins as specific biomarkers for cancer

MJ Kailemia, D Park, CB Lebrilla - Analytical and bioanalytical chemistry, 2017 - Springer
Protein glycosylation and other post-translational modifications are involved in potentially all
aspects of human growth and development. Defective glycosylation has adverse effects on …

The sweet and sour of serological glycoprotein tumor biomarker quantification

U Kuzmanov, H Kosanam, EP Diamandis - BMC medicine, 2013 - Springer
Aberrant and dysregulated protein glycosylation is a well-established event in the process of
oncogenesis and cancer progression. Years of study on the glycobiology of cancer have …

Alterations in glycosylation as biomarkers for cancer detection

CA Reis, H Osorio, L Silva, C Gomes… - Journal of clinical …, 2010 - jcp.bmj.com
Glycoconjugates constitute a major class of biomolecules which include glycoproteins,
glycosphingolipids and proteoglycans. Glycans are involved in several physiological and …

The prospects of glycan biomarkers for the diagnosis of diseases

CB Lebrilla, HJ An - Molecular bioSystems, 2009 - pubs.rsc.org
Over 40 years of literature shows that glycosylation is greatly affected by diseases such as
cancer. This opinion article argues the intrinsic advantages of using glycans as disease …

Aberrant glycosylation and cancer biomarker discovery: a promising and thorny journey

M Wang, J Zhu, DM Lubman, C Gao - Clinical Chemistry and …, 2019 - degruyter.com
Glycosylation is among the most important post-translational modifications for proteins and
is of intrinsic complex character compared with DNAs and naked proteins. Indeed, over 50 …

Glycosylation‐based serum biomarkers for cancer diagnostics and prognostics

A Kirwan, M Utratna, ME O'Dwyer… - BioMed research …, 2015 - Wiley Online Library
Cancer is the second most common cause of death in developed countries with
approximately 14 million newly diagnosed individuals and over 6 million cancer‐related …

Glycans as cancer biomarkers

B Adamczyk, T Tharmalingam, PM Rudd - Biochimica et Biophysica Acta …, 2012 - Elsevier
BACKGROUND: Non-invasive biomarkers, such as those from serum, are ideal for disease
prognosis, staging and monitoring. In the past decade, our understanding of the importance …

Mass spectrometry based glycoproteomics—from a proteomics perspective

S Pan, R Chen, R Aebersold, TA Brentnall - Molecular & cellular …, 2011 - ASBMB
Glycosylation is one of the most important and common forms of protein post-translational
modification that is involved in many physiological functions and biological pathways …

Developments in the identification of glycan biomarkers for the detection of cancer

LR Ruhaak, S Miyamoto, CB Lebrilla - Molecular & Cellular Proteomics, 2013 - ASBMB
Changes in glycosylation readily occur in cancer and other disease states. Thanks to recent
advances in the development of analytical techniques and instrumentation, especially in …

Cell surface protein glycosylation in cancer

MN Christiansen, J Chik, L Lee, M Anugraham… - …, 2014 - Wiley Online Library
Glycosylation of proteins is one of the most important PTMs, with more than half of all human
proteins estimated to be glycosylated. It is widely known that aberrant glycosylation has …