Abstract Rb+/+: Rb−/− chimeric mice are healthy until early in adulthood when they develop
lethal pituitary tumors composed solely of Rb−/− cells. In an effort to delineate the minimal …

To assess biological roles of the retinoblastoma protein (RB), four independent transgenic
mouse lines expressing human RB with different deletions in the N-terminal region (RBΔN) …

The requirement for a functional retinoblastoma gene, Rb‐1, in murine development around
days 12‐15 of gestation precludes monitoring the effect of loss of Rb‐1 function on later …

Homozygosity for a mutation in the Rb tumor suppressor gene causes mid‐gestation
embryonic lethality in the mouse. Using a two‐step targeting protocol, we have constructed …

The identification of the retinoblastoma gene (rb) has sparked intense inves tigation of tumor
suppressor genes. These genes, like oncogenes, can encode transcriptional regulators …

Mutational inactivation of the retinoblastoma (RB) gene has been implicated in the genesis
of retinoblastoma, osteosarcoma, and other human tumors. Our strategy has been to …

The retinoblastoma gene family consists of three genes: RB, p107, and p130. While loss of
pRB causes retinoblastoma in humans and pituitary gland tumors in mice, tumorigenesis in …

The retinoblastoma susceptibility gene product functions to prevent neoplastic
transformation in a variety of cell types. Inactivation of the retinoblastoma gene (RB) is …

Mutational inactivation of the retinoblastoma gene (RB) is an invariant feature of the
childhood eye cancer retinoblastoma and of tumor cells derived therefrom. In a previous …

The retinoblastoma tumor suppressor (RB) plays an important role in the regulation of cell
cycle progression and terminal differentiation of many cell types. Rb−/− mouse embryos die …