Activation of gonadotropin-releasing hormone (GnRH) receptors inhibits proliferation of
transformed cells derived from reproductive tissues and in transfected cell lines. Hence …

GnRH and its receptor are expressed in human reproductive tract cancers, and direct
antiproliferative effects of GnRH analogs have been demonstrated in cancer cell lines. The …

Gonadotropin-releasing hormone (GnRH) receptor activation has been demonstrated to
inhibit cell proliferation in vitro and in vivo. These effects are dependent on the degree of …

Gonadotropin-releasing hormone (GnRH) is the hypothalamic factor that mediates
reproductive competence. Intermittent GnRH secretion from the hypothalamus acts upon its …

The mechanism by which gonadotropin-releasing hormone (GnRH) agonists and
antagonists inhibit tumor cell growth and proliferation is controversial. Direct mediation of the …

Gonadotropin-releasing hormone (GnRH), a decapeptide, is a part of the hypothalamic-
pituitary-gonadal axis, and being a part of this system makes it vital for human reproduction …

Continuous administration of GnRH analogs results in an inhibition of tumor growth that may
be mediated in part by direct activation of GnRH receptors (GnRHRs) expressed on tumor …

Abstract GnRH receptors (GnRH-Rs) mediate direct antiproliferative effects on hormone-
dependent cancer cells. GnRH-Rs can be grouped according to ligand specificity (for GnRH …

In several human malignant tumors of the urogenital tract, including cancers of the
endometrium, ovary, urinary bladder, and prostate, it has been possible to identify …

Gonadotropin releasing hormone (GnRH) and its analogs inhibit the growth of hormone-
dependent tumors in vivo and in vitro. The inhibition of growth and proliferation of tumor cells …