Human Serum Albumin Nanoparticles as a Carrier of 20(S)-Protopanaxadiol via Intramuscular Injection to Alleviate Cyclophosphamide-Induced Myelosuppression
L Liu, B Yang, H Yuan, N Yu, Y Feng… - Molecular …, 2023 - ACS Publications
Myelosuppression is a prevalent and potentially life-threatening side effect during
chemotherapy. As the main active component of ginseng, 20 (S)-protopanaxadiol (PPD) is …
chemotherapy. As the main active component of ginseng, 20 (S)-protopanaxadiol (PPD) is …
Formulation of 20 (S)-protopanaxadiol nanocrystals to improve oral bioavailability and brain delivery
C Chen, L Wang, F Cao, X Miao, T Chen… - International Journal of …, 2016 - Elsevier
The aim of this study was to fabricate 20 (S)-protopanaxadiol (PPD) nanocrystals to improve
PPD's oral bioavailability and brain delivery. PPD nanocrystals were fabricated using an anti …
PPD's oral bioavailability and brain delivery. PPD nanocrystals were fabricated using an anti …
[HTML][HTML] Prevention effect of protopanaxadiol-type saponins saponins and protopanaxatriol-type saponins on myelosuppression mice induced by cyclophosphamide
H Zhang, L Zhang, C Yang, Y Zhang, J Li… - Frontiers in …, 2022 - frontiersin.org
Ginsenosides from ginseng are used as a therapeutic agent for various diseases. They
enhance the immunomodulatory effect in cyclophosphamide (CP)-treated tumor disease …
enhance the immunomodulatory effect in cyclophosphamide (CP)-treated tumor disease …
Ginseng-derived panaxadiol saponins promote hematopoiesis recovery in cyclophosphamide-induced myelosuppressive mice: potential novel treatment of …
X Sun, Y Zhao, S Qian, R Gao, L Yin, L Wang… - Chinese journal of …, 2018 - Springer
Objective To investigate the potential efficacy of panaxadiol saponins component (PDS-C), a
biologically active fraction isolated from total ginsenosides, to reverse chemotherapy …
biologically active fraction isolated from total ginsenosides, to reverse chemotherapy …
Saikosaponin-a loaded methoxy poly (ethylene glycol)-poly (ε-caprolactone) nanoparticles for improved solubility and reduced hemolysis of Saikosaponin-a
M Zhou, W Xie, Y Hong, N Deng, Y Wang, Y Zhu - Materials Letters, 2018 - Elsevier
Methoxy poly (ethylene glycol)-poly (ε-caprolactone)(MePEG-PCL) nanoparticles (NPs)
were fabricated using an emulsion solvent evaporation technique, aiming at improving the …
were fabricated using an emulsion solvent evaporation technique, aiming at improving the …
Alpha-tocopheryl polyethylene glycol succinate-emulsified poly (lactic-co-glycolic acid) nanoparticles for reversal of multidrug resistance in vitro
Y Wang, M Guo, Y Lu, LY Ding, WT Ron, YQ Liu… - …, 2012 - iopscience.iop.org
Multidrug resistance (MDR) is one of the factors in the failure of anticancer chemotherapy. In
order to enhance the anticancer effect of P-glycoprotein (P-gp) substrates, inhibition of the P …
order to enhance the anticancer effect of P-glycoprotein (P-gp) substrates, inhibition of the P …
A nanoparticulate drug-delivery system for 20 (S)-protopanaxadiol: formulation, characterization, increased oral bioavailability and anti-tumor efficacy
M Han, L Ma, X Yu, Z Li, Y Guo, X Wang - Drug delivery, 2016 - Taylor & Francis
As with many other hydrophobic anticancer agents, 20 (S)-protopanaxadiol (PPD) has a
very low oral bioavailability. In this study, a precipitation-combined ultrasonication technique …
very low oral bioavailability. In this study, a precipitation-combined ultrasonication technique …
Nanoencapsulation improves scavenging capacity and decreases cytotoxicity of silibinin and pomegranate oil association
MCL Marchiori, C Rigon, PM Copetti, MR Sagrillo… - Aaps Pharmscitech, 2017 - Springer
Silibinin (SB) and pomegranate oil (PO) present therapeutic potential due to antioxidant
activity, but the biological performance of both bioactives is limited by their low aqueous …
activity, but the biological performance of both bioactives is limited by their low aqueous …
Enhanced oral absorption of 20 (S)-protopanaxadiol by self-assembled liquid crystalline nanoparticles containing piperine: in vitro and in vivo studies
X Jin, Z Zhang, E Sun, X Tan, S Li… - International journal …, 2013 - Taylor & Francis
Background 20 (S)-protopanaxadiol (PPD), similar to several other anticancer agents, has
low oral absorption and is extensively metabolized. These factors limit the use of PPD for …
low oral absorption and is extensively metabolized. These factors limit the use of PPD for …
[HTML][HTML] BioPerine encapsulated nanoformulation for overcoming drug-resistant breast cancers
The evolving dynamics of drug resistance due to tumor heterogeneity often creates
impediments to traditional therapies making it a challenging issue for cancer cure. Breast …
impediments to traditional therapies making it a challenging issue for cancer cure. Breast …