Potentiation of natural killer cells to overcome cancer resistance to NK cell-based therapy and to enhance antibody-based immunotherapy

M Fantini, PM Arlen, KY Tsang - Frontiers in Immunology, 2023 - frontiersin.org
Natural killer (NK) cells are cellular components of the innate immune system that can
recognize and suppress the proliferation of cancer cells. NK cells can eliminate cancer cells …

The application of natural killer cell immunotherapy for the treatment of cancer

K Rezvani, RH Rouce - Frontiers in immunology, 2015 - frontiersin.org
Natural killer (NK) cells are essential components of the innate immune system and play a
critical role in host immunity against cancer. Recent progress in our understanding of NK cell …

Next generation natural killer cells for cancer immunotherapy

F Rossi, N Fredericks, A Snowden… - Frontiers in …, 2022 - frontiersin.org
In recent years, immunotherapy for cancer has become mainstream with several products
now authorized for therapeutic use in the clinic and are becoming the standard of care for …

Next generation immuno-oncology strategies: unleashing NK cells activity

A Mendoza-Valderrey, M Alvarez, A De Maria… - Cells, 2022 - mdpi.com
In recent years, immunotherapy has become a powerful therapeutic option against multiple
malignancies. The unique capacity of natural killer (NK) cells to attack cancer cells without …

Natural killer cell-based therapies targeting cancer: possible strategies to gain and sustain anti-tumor activity

CIM Dahlberg, D Sarhan, M Chrobok, AD Duru… - Frontiers in …, 2015 - frontiersin.org
Natural killer (NK) cells were discovered 40 years ago, by their ability to recognize and kill
tumor cells without the requirement of prior antigen exposure. Since then, NK cells have …

Harnessing natural killer cells in cancer immunotherapy: a review of mechanisms and novel therapies

F St-Pierre, S Bhatia, S Chandra - Cancers, 2021 - mdpi.com
Simple Summary Cancer immunotherapy has mostly focused on harnessing adaptive
immunity to promote the destruction of neoplastic cells by B and T lymphocytes. We are now …

Natural killer cells: the linchpin for successful cancer immunotherapy

KA Shaver, TJ Croom-Perez, AJ Copik - Frontiers in immunology, 2021 - frontiersin.org
Cancer immunotherapy is a highly successful and rapidly evolving treatment modality that
works by augmenting the body's own immune system. While various immune stimulation …

Combination immune therapies to enhance anti-tumor responses by NK cells

A Mentlik James, AD Cohen, KS Campbell - Frontiers in immunology, 2013 - frontiersin.org
Natural killer (NK) cells are critical innate immune lymphocytes capable of destroying virally
infected or cancerous cells through targeted cytotoxicity and further assisting in the immune …

Leveraging natural killer cells for cancer immunotherapy

SK Grossenbacher, EG Aguilar, WJ Murphy - Immunotherapy, 2017 - Taylor & Francis
Natural killer (NK) cells are potent antitumor effector cells of the innate immune system.
Based on their ability to eradicate tumors in vitro and in animal models, significant …

Antibody-dependent cell-mediated cytotoxicity through Natural Killer (NK) cells: Unlocking NK cells for future immunotherapy

DS Chin, CSY Lim, F Nordin, N Arifin… - Current Pharmaceutical …, 2022 - ingentaconnect.com
Background: Natural killer (NK) cells have potent effector functions that can be further
improved for therapeutic purposes through antibody-dependent cell-mediated cytotoxicity …