Background: Cancer has profound effects on gene expression, including a cell's
glycosylation machinery. Thus, tumors produce glycoproteins that carry oligosaccharides …

Aberrant and dysregulated protein glycosylation is a well-established event in the process of
oncogenesis and cancer progression. Years of study on the glycobiology of cancer have …

Background Complex diseases such as cancer are a consequence of numerous causes.
State of the art personalised medicine approaches are mostly based on evaluating patients' …

Glycosylation is among the most important post-translational modifications for proteins and
is of intrinsic complex character compared with DNAs and naked proteins. Indeed, over 50 …

Alteration of glycosylation, a hallmark of cancer, results in the production of tumor-
associated glycans or glycoproteins. These molecules are subsequently secreted or …

Glycosylation-mediated post-translational modification is critical for regulating many
fundamental processes like cell division, differentiation, immune response, and cell-to-cell …

Protein glycosylation is one of the most common post-translational modifications that are
essential for cell function across all domains of life. Changes in glycosylation are considered …

Cancer is a deadly disease that encompasses numerous cellular modifications. Among
them, alterations in glycosylation are a proven reliable hallmark of cancer, with most …

Detection of cancer at early stages that can be treated through surgery is a difficult task. One
methodology for cancer biomarker discovery exploits the fact that glycoproteins produced by …

Glycosylation is the most structurally complicated and diverse type of protein modifications.
Protein glycosylation has long been recognized to play fundamental roles in many biological …