Transcriptional regulation of the antioxidant response element: activation by Nrf2 and repression by MafK
T Nguyen, HC Huang, CB Pickett - Journal of Biological Chemistry, 2000 - ASBMB
The antioxidant response element (ARE) mediates the transcriptional activation of many
genes encoding phase II drug-metabolizing enzymes in response to oxidative stress. Recent …
genes encoding phase II drug-metabolizing enzymes in response to oxidative stress. Recent …
Nrf2 transcriptionally activates the mafG gene through an antioxidant response element
F Katsuoka, H Motohashi, JD Engel… - Journal of Biological …, 2005 - ASBMB
Nrf2 accumulates in nuclei upon exposure to oxidative stress, heterodimerizes with a small
Maf protein, and activates the transcription of stress target genes through antioxidant …
Maf protein, and activates the transcription of stress target genes through antioxidant …
The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress
T Nguyen, CS Yang, CB Pickett - Free Radical Biology and Medicine, 2004 - Elsevier
The induction of many antioxidant and phase II drug-metabolizing enzymes by phenolic
antioxidants and electrophilic compounds is regulated at the transcriptional level. The …
antioxidants and electrophilic compounds is regulated at the transcriptional level. The …
Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element: degradation of Nrf2 by the 26 S …
T Nguyen, PJ Sherratt, HC Huang, CS Yang… - Journal of Biological …, 2003 - ASBMB
Nrf2 (NF-E2-related factor 2) is a central transcription factor involved in the transcriptional
activation of many genes encoding phase II drug-metabolizing enzymes via the antioxidant …
activation of many genes encoding phase II drug-metabolizing enzymes via the antioxidant …
Novel insights into the regulation of antioxidant-response-elementmediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by …
HK Jyrkkänen, S Kuosmanen, M Heinäniemi… - Biochemical …, 2011 - portlandpress.com
A central mechanism in cellular defence against oxidative or electrophilic stress is mediated
by transcriptional induction of genes via the ARE (antioxidant-response element), a cis …
by transcriptional induction of genes via the ARE (antioxidant-response element), a cis …
Regulatory mechanisms controlling gene expression mediated by the antioxidant response element
T Nguyen, PJ Sherratt, CB Pickett - Annual review of …, 2003 - annualreviews.org
The expression of genes encoding antioxidative and Phase II detoxification enzymes is
induced in cells exposed to electrophilic compounds and phenolic antioxidants. Induction of …
induced in cells exposed to electrophilic compounds and phenolic antioxidants. Induction of …
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
K Itoh, T Chiba, S Takahashi, T Ishii, K Igarashi… - Biochemical and …, 1997 - Elsevier
The induction of phase II detoxifying enzymes is an important defense mechanism against
intake of xenobiotics. While this group of enzymes is believed to be under the transcriptional …
intake of xenobiotics. While this group of enzymes is believed to be under the transcriptional …
Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes
M Ohtsuji, F Katsuoka, A Kobayashi, H Aburatani… - Journal of Biological …, 2008 - ASBMB
Nrf1 is a member of the vertebrate Cap'n'Collar (CNC) transcription factor family that
commonly contains a unique basic-leucine zipper domain. Among CNC family members …
commonly contains a unique basic-leucine zipper domain. Among CNC family members …
Regulatory mechanisms of cellular response to oxidative stress
K Itoh, T Ishii, N Wakabayashi… - Free radical research, 1999 - Taylor & Francis
An antioxidant responsive element (ARE) or electrophile responsive element (EpRE)
mediates the transcriptional activation of genes encoding phase II drug metabolizing …
mediates the transcriptional activation of genes encoding phase II drug metabolizing …
Nrf2 signaling in coordinated activation of antioxidant gene expression
AK Jaiswal - Free Radical Biology and Medicine, 2004 - Elsevier
Antioxidant response element (ARE)-mediated expression and coordinated induction of
antioxidant enzymes is a critical mechanism of protection against chemically induced …
antioxidant enzymes is a critical mechanism of protection against chemically induced …
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