In acute experimental autoimmune encephalomyelitis, infiltrating macrophages are immune activated, whereas microglia remain immune suppressed

ID Vainchtein, J Vinet, N Brouwer, S Brendecke… - Glia, 2014 - Wiley Online Library
Multiple sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous
system (CNS) characterized by loss of myelin accompanied by infiltration of T‐lymphocytes …

Macrophages: a double-edged sword in experimental autoimmune encephalomyelitis

Z Jiang, JX Jiang, GX Zhang - Immunology letters, 2014 - Elsevier
Multiple sclerosis (MS) is a debilitating neurological disorder of the central nervous system
(CNS), characterized by activation and infiltration of leukocytes and dendritic cells into the …

The roles of macrophages and microglia in multiple sclerosis and experimental autoimmune encephalomyelitis

F Chu, M Shi, C Zheng, D Shen, J Zhu, X Zheng… - Journal of …, 2018 - Elsevier
Multiple sclerosis (MS) is an autoimmune and neurodegenerative disorder characterized by
chronic inflammation, demyelination, as well as axonal and neuronal loss in the central …

Microglial cell activation and proliferation precedes the onset of CNS autoimmunity

ED Ponomarev, LP Shriver, K Maresz… - Journal of …, 2005 - Wiley Online Library
Microglial cells are central nervous system (CNS) resident cells that are thought to become
activated and contribute to the inflammation that occurs in the human autoimmune disease …

[HTML][HTML] Microglia and meningeal macrophages depletion delays the onset of experimental autoimmune encephalomyelitis

A Montilla, A Zabala, M Er-Lukowiak, B Rissiek… - Cell Death & …, 2023 - nature.com
In multiple sclerosis and the experimental autoimmune encephalomyelitis (EAE) model, both
resident microglia and infiltrating macrophages contribute to demyelination as well as …

Differential roles of microglia and monocytes in the inflamed central nervous system

R Yamasaki, H Lu, O Butovsky, N Ohno… - Journal of Experimental …, 2014 - rupress.org
In the human disorder multiple sclerosis (MS) and in the model experimental autoimmune
encephalomyelitis (EAE), macrophages predominate in demyelinated areas and their …

CD8+ phagocyte recruitment in rat experimental autoimmune encephalomyelitis: association with inflammatory tissue destruction

M Schroeter, G Stoll, R Weissert, HP Hartung… - The American journal of …, 2003 - Elsevier
Increasing evidence suggests an important role of CD8+ cells in the pathogenesis of
multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE) …

Microglia in central nervous system inflammation and multiple sclerosis pathology

S Voet, M Prinz, G van Loo - Trends in molecular medicine, 2019 - cell.com
Microglia are the resident macrophages of the central nervous system (CNS). They have
important physiological functions in maintaining tissue homeostasis but also contribute to …

The benefits and detriments of macrophages/microglia in models of multiple sclerosis

KS Rawji, VW Yong - Journal of Immunology Research, 2013 - Wiley Online Library
The central nervous system (CNS) is immune privileged with access to leukocytes being
limited. In several neurological diseases, however, infiltration of immune cells from the …

[HTML][HTML] Role of peripheral immune cells in multiple sclerosis and experimental autoimmune encephalomyelitis

S Dhaiban, M Al-Ani, NM Elemam, MH Al-Aawad… - Sci, 2021 - mdpi.com
Multiple sclerosis (MS) is a chronic autoimmune disease that affects the myelination of the
neurons present in the central nervous system (CNS). The exact etiology of MS development …