Background Intratumoral hypoxia and epithelial–mesenchymal transition are involved in
tumor invasion and metastasis. Aims This study investigated the molecular mechanisms that …

Background High invasion and metastasis are the primary factors causing poor prognosis of
patients with hepatocellular carcinoma (HCC). However, the molecular mechanisms …

Hypoxia is a microenvironmental factor which plays a critical role in tumor development and
chemoresistance. Epithelial-to-mesenchymal transition (EMT) induced by hypoxia is one of …

Hypoxia has been involved in the development of tumor by regulating the expression of
invasiveness-associated genes. However, the specific function of hypoxia in cancer cell …

Background: Intratumoral hypoxia is known to lead to increased aggressiveness and distant
metastasis. However, the interplay underlying these actions is still unknown. Objective: We …

Objectives This study aimed to investigate the effect and mechanism of hypoxia on
pancreatic cancer (PC) cell dedifferentiation and tumorigenic potential. Methods Inhibition of …

Background/Aim: Recent studies implied a significant role of hypoxia-inducible factor-1α
(HIF1α) in cell transformation. This study aimed to assess the effects of HIF1α on the …

Pancreatic cancer is one of the common malignant tumors of the digestive system and is
known as the “king of cancers”. It is extremely difficult to diagnose at an early stage, the …

Purpose Hypoxia is an indispensable factor in the progression of metastasis. Hypoxia
inducible factor-1α (HIF-1α), the core element in generating the hypoxia response, induces …

In general, tumors cells that are resistant to apoptosis and increase angiogenesis are a
result of the hypoxic responses contributing to the malignant phenotype. In this study, we …