Multidrug efflux is a major contributor to antibiotic resistance in Gram-negative bacterial
pathogens. Inhibition of multidrug efflux pumps is a promising approach for reviving the …

In Gram-negative bacteria, efflux pumps are able to prevent effective cellular concentrations
from being achieved for a number of antibiotics. Small molecule adjuvants that act as efflux …

Efflux is an important mechanism in Gram-negative bacteria conferring multidrug resistance.
Inhibition of efflux is an encouraging strategy to restore the antibacterial activity of antibiotics …

Antibiotic resistance poses an immediate and growing threat to human health. Multidrug
efflux pumps are promising targets for overcoming antibiotic resistance with small-molecule …

Efflux pumps of the resistance nodulation division (RND) superfamily, such as AcrB, make a
major contribution to multidrug resistance in Gram-negative bacteria. The development of …

Optimization of compound permeation into Gram-negative bacteria is one of the most
challenging tasks in the development of antibacterial agents. Two permeability barriers─ …

Bacterial infections are an increasingly serious issue worldwide. The inability of existing
therapies to treat multidrug‐resistant pathogens has been recognized as an important …

Antibiotic resistance is a major threat to human welfare. Inhibitors of multidrug efflux pumps
(EPIs) are promising alternative therapeutics that could revive activities of antibiotics and …

Multidrug efflux pumps adversely affect both the clinical effectiveness of existing antibiotics
and the discovery process to find new ones. In this study, we reconstituted and characterized …

The Escherichia coli AcrAB-TolC efflux pump is the archetype of the resistance nodulation
cell division (RND) exporters from Gram-negative bacteria. Overexpression of RND-type …