In studies of the SAR of phenethylamine-type serotonin 5-HT2A receptor agonists,
substituted conformationally constrained tetrahydronaphthofurans were designed to …

A structure-activity analysis was used to identify selective 5-HT 1A versus 5-HT 1D receptor
agents. An analysis of published data identified 13 drugs which display nanomolar affinity …

In receptor binding assays (±) MDL 72832, 8-[4-(1, 4-benzodioxan-2-ylmethylamino) butyl] 8-
azaspiro [4, 5] decane-7, 9-dione, was a potent (pIC 50 9.1), selective and stereospecific …

MH. MZ, MDL 100907, and altanserin are structurally similar 4‐benzoyl‐piperidine
derivatives and are well accommodated to receptor interaction models. We combined …

A major focus of our research for a number of years has been to understand the structure-
activity relationship (SAR) of classical hallucinogens and their derivatives, the …

Experiments were conducted to examine the molecular basis for the high affinity and
potency of a new class of 5-HT2A receptor agonists, N-benzyl phenethylamines …

The affinity of ligands for either the 5-HT2A or 5-HT2C agonist binding site was enhanced by
modification of the 2, 5-oxygen substituents that are found in typical hallucinogenic …

Abstract Serotonin (5-HT) is a potent bioactive substance known to function through a
number of different receptor types and subtypes. In our attempt to develop new agents that …

Novel 5-HT3 receptor ligands were designed and synthesized with the aim of obtaining
deeper insight into the molecular basis of the intrinsic efficacy of arylpiperazines interacting …

The lipophilicity of a set of 5-HT2A ligands was determined using immobilized-artificial-
membrane chromatography, a method that generates values well correlated with octanol …