Recent studies have revealed that the mammalian immune system directly interferes with
siderophore-mediated iron acquisition through siderophore-binding proteins and that the …

Iron is required for virulence of most bacterial pathogens, many of which rely on
siderophores, small-molecule chelators, to scavenge iron in mammalian hosts. As an …

Bacterial pathogens use siderophores to obtain iron from the host in order to survive and
grow. The host defends against siderophore-mediated iron acquisition by producing …

Bacteria use tight-binding, ferric-specific chelators called siderophores to acquire iron from
the environment and from the host during infection; animals use proteins such as transferrin …

Conspectus This Account focuses on the coordination chemistry of the microbial iron
chelators called siderophores. The initial research (early 1970s) focused on simple analogs …

Systemic anthrax, caused by inhalation or ingestion of Bacillus anthracis spores, is
characterized by rapid microbial growth stages that require iron. Tightly bound and highly …

High-affinity iron acquisition is mediated by siderophore-dependent pathways in the majority
of pathogenic and nonpathogenic bacteria and fungi. Considerable progress has been …

The siderophore enterobactin (Ent) is produced by enteric bacteria to mediate iron uptake.
Ent scavenges iron and is taken up by the bacteria as the highly stable ferric complex [FeIII …

Competition for iron influences host–pathogen interactions. Pathogens secrete small iron-
binding moieties, siderophores, to acquire host iron. In response, the host secretes …

Microorganisms use siderophores to obtain iron from the environment. In pathogenic
interactions, siderophores are involved in iron acquisition from the host and are sometimes …