Systemic inflammation is a potent prothrombotic stimulus. Inflammatory mechanisms
upregulate procoagulant factors, downregulate natural anticoagulants and inhibit fibrinolytic …

Inflammation initiates clotting, decreases the activity of natural anticoagulant mechanisms
and impairs the fibrinolytic system. Inflammatory cytokines are the major mediators involved …

Inflammation and coagulation play pivotal roles in host defence. As phylogenetically old
responses, there is extensive cross-talk between inflammation and coagulation in enabling …

Activation of inflammatory and coagulation pathways is important in the pathogenesis of
vascular disease. There is ample evidence that extensive cross-talk between these two …

In the majority of patients with systemic inflammatory conditions, some degree of activation
of coagulation is present. Increasing evidence points to an extensive cross‐talk between …

Anatomic pathology studies performed over 150 years ago revealed that excessive
activation of coagulation occurs in the setting of inflammation. However, it has taken over a …

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The association between inflammation, infection, and venous thrombosis has long been
recognized; yet, only in the last decades have we begun to understand the mechanisms …

Inflammation contributions to the thrombotic response involve both cellular and humoral
modulation. Inflammation impacts the initiation, propagation and the inhibitory phases of …

Thrombosis with associated inflammation (thromboinflammation) occurs commonly in a
broad range of human disorders. It is well recognized clinically in the context of superficial …