Effects of alcohol and cocaine in a mutant mouse model of predisposition to post-traumatic stress disorder

E Paizanis, M Crotti, A Petit, M Règue… - Frontiers in …, 2020 - frontiersin.org
Comorbidity between drug abuse and post-traumatic stress disorder (PTSD), a stress-
related dysregulation of fear responses, is very high. While some drugs are known to …

Genetic correlation between alcohol preference and conditioned fear: Exploring a functional relationship

JA Chester, MM Weera - Alcohol, 2017 - Elsevier
Post-traumatic stress disorder (PTSD) and alcohol-use disorders have a high rate of co-
occurrence, possibly because they are regulated by common genes. In support of this idea …

Sex and context differences in the effects of trauma on comorbid alcohol use and post‐traumatic stress phenotypes in actively drinking rats

D Kirson, MQ Steinman, SA Wolfe… - Journal of …, 2021 - Wiley Online Library
Alcohol use disorder (AUD) and affective disorders are frequently comorbid and share
underlying mechanisms that could be targets for comprehensive treatment. Post‐traumatic …

Fear conditioning in mouse lines genetically selected for binge-like ethanol drinking

JC Crabbe, JP Schlumbohm, W Hack… - Alcohol, 2016 - Elsevier
The comorbidity of substance-and alcohol-use disorders (AUD) with other psychiatric
conditions, especially those related to stress such as post-traumatic stress disorder (PTSD) …

Increased 5-HT2C receptor editing predisposes to PTSD-like behaviors and alters BDNF and cytokines signaling

M Règue, C Poilbout, V Martin, B Franc… - Translational …, 2019 - nature.com
Post-traumatic stress disorder (PTSD) is a trauma-and stress-related disorder with
dysregulated fear responses and neurobiological impairments, notably at neurotrophic and …

Importance of sex and trauma context on circulating cytokines and amygdalar GABAergic signaling in a comorbid model of posttraumatic stress and alcohol use …

MQ Steinman, D Kirson, SA Wolfe, S Khom… - Molecular …, 2021 - nature.com
Alcohol use disorder (AUD) and anxiety disorders are frequently comorbid and share
mechanisms that could be therapeutic targets. To facilitate mechanistic studies, we adapted …

Investigating the Bidirectional Relationship between Cocaine-Induced Locomotor Sensitization and Posttraumatic Stress Disorder-Like in Dba/2j Mice

T Matonda-ma-Nzuzi, V Didone, L Godefroid… - Available at SSRN … - papers.ssrn.com
To date, the relationship between cocaine use disorder and posttraumatic stress disorder
(PTSD) remains poorly understood. A few animal studies reported evidence that PTSD-like …

Genetic model to study the co-morbid phenotypes of increased alcohol intake and prior stress-induced enhanced fear memory

PH Lim, G Shi, T Wang, ST Jenz, MK Mulligan… - Frontiers in …, 2018 - frontiersin.org
Posttraumatic Stress Disorder (PTSD) is a complex illness, frequently co-morbid with
depression, caused by both genetics, and the environment. Alcohol Use Disorder (AUD) …

Chemogenetic inhibition of central amygdala CRF-expressing neurons decreases alcohol intake but not trauma-related behaviors in a rat model of post-traumatic …

B Cruz, V Vozella, V Borgonetti, R Bullard… - Molecular …, 2024 - nature.com
Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are often comorbid.
Few treatments exist to reduce comorbid PTSD/AUD. Elucidating the mechanisms …

Investigating the reciprocal relationships between locomotor sensitization to ethanol and PTSD-like clusters in DBA/2J mice

T Matonda-ma-Nzuzi, V Didone, V Seutin… - Behavioural Brain …, 2019 - Elsevier
Background Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are two
conditions that co-occur frequently. The mechanistic explanations of this co-morbidity are …