DNA methylation is one of the most intensely studied epigenetic modifications in mammals.
In normal cells, it assures the proper regulation of gene expression and stable gene …

The spatial arrangement and three-dimensional structure of DNA in the nucleus is controlled
through the interdigitation of DNA binding proteins such as histones and their modifiers, the …

Recent conceptual advances in the field of DNA methylation and the advent and rapid
development of new technologies in epigenomics have started to unravel the mechanisms …

Epigenetic alterations such as DNA methylation have been implicated in the development
and progression of various cancers. DNA methylation consists of the reversible addition of a …

DNA methylation acts in concert with other epigenetic mechanisms to regulate normal gene
expression and facilitate chromatin organization within cells. Aberrant DNA methylation …

DNA methylation is a major epigenetic modification that is strongly involved in the
physiological control of genome expression. DNA methylation patterns are largely modified …

DNA methylation plays an important role in regulating normal development and
carcinogenesis. Current understanding of the biological roles of DNA methylation is limited …

There is compelling evidence to support the importance of DNA methylation alterations in
cancer development. Both losses and gains of DNA methylation are observed, thought to …

DNA methylation is a significant regulator of gene expression, and its role in carcinogenesis
recently has been a subject of remarkable interest. The aim of this review is to analyze the …

The methylation of DNA is an epigenetic modification that can play an important role in the
control of gene expression in mammalian cells. The enzyme involved in this process is DNA …