Preclinical studies for induced pluripotent stem cell-based therapeutics
J Harding, O Mirochnitchenko - Journal of Biological Chemistry, 2014 - ASBMB
Induced pluripotent stem cells (iPSCs) and their differentiated derivatives can potentially be
applied to cell-based therapy for human diseases. The properties of iPSCs are being …
applied to cell-based therapy for human diseases. The properties of iPSCs are being …
The immunogenicity and immune tolerance of pluripotent stem cell derivatives
X Liu, W Li, X Fu, Y Xu - Frontiers in immunology, 2017 - frontiersin.org
Human embryonic stem cells (hESCs) can undergo unlimited self-renewal and differentiate
into all cell types in human body, and therefore hold great potential for cell therapy of …
into all cell types in human body, and therefore hold great potential for cell therapy of …
CAR-NK cells from engineered pluripotent stem cells: Off-the-shelf therapeutics for all patients
SJ Lu, Q Feng - Stem Cells Translational Medicine, 2021 - academic.oup.com
Clinical success of adoptive cell therapy with chimeric antigen receptor (CAR) T cells for
treating hematological malignancies has revolutionized the field of cellular immunotherapy …
treating hematological malignancies has revolutionized the field of cellular immunotherapy …
Reprogramming away from the exhausted T cell state
P Karagiannis, S Iriguchi, S Kaneko - Seminars in immunology, 2016 - Elsevier
Induced pluripotent stem cells (iPSCs) describe somatic cells that have been reprogrammed
to the pluripotent state from which they can then be differentiated into any cell type of the …
to the pluripotent state from which they can then be differentiated into any cell type of the …
Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy
Progress in adoptive T-cell therapy for cancer and infectious diseases, is hampered by the
lack of readily available, antigen-specific, human T lymphocytes. Pluripotent stem cells could …
lack of readily available, antigen-specific, human T lymphocytes. Pluripotent stem cells could …
Research and therapy with induced pluripotent stem cells (iPSCs): social, legal, and ethical considerations
S Moradi, H Mahdizadeh, T Šarić, J Kim… - Stem cell research & …, 2019 - Springer
Induced pluripotent stem cells (iPSCs) can self-renew indefinitely in culture and differentiate
into all specialized cell types including gametes. iPSCs do not exist naturally and are …
into all specialized cell types including gametes. iPSCs do not exist naturally and are …
[HTML][HTML] Pluripotent stem cell-based cell therapy—promise and challenges
S Yamanaka - Cell stem cell, 2020 - cell.com
Human pluripotent stem cells such as embryonic stem cells (ESCs) and induced pluripotent
stem cells (iPSCs) provide unprecedented opportunities for cell therapies against intractable …
stem cells (iPSCs) provide unprecedented opportunities for cell therapies against intractable …
Differentiation of mesenchymal stem cells from human induced pluripotent stem cells results in downregulation of c-Myc and DNA replication pathways with …
LT Wang, SS Jiang, CH Ting, PJ Hsu, CC Chang… - Stem Cells, 2018 - academic.oup.com
Multilineage tissue-source mesenchymal stem cells (MSCs) possess strong
immunomodulatory properties and are excellent therapeutic agents, but require constant …
immunomodulatory properties and are excellent therapeutic agents, but require constant …
[HTML][HTML] FT596: translation of first-of-kind multi-antigen targeted off-the-shelf CAR-NK cell with engineered persistence for the treatment of B cell malignancies
Induced pluripotent stem cell (iPSC)-derived effector cells offer distinct advantages for
immune therapy over existing patient-or donor-derived platforms, both in terms of scalable …
immune therapy over existing patient-or donor-derived platforms, both in terms of scalable …
Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients
Autologous induced pluripotent stem cells (iPSCs) constitute an unlimited cell source for
patient-specific cell-based organ repair strategies. However, their generation and …
patient-specific cell-based organ repair strategies. However, their generation and …