Abstract Endogenous Pain Modulation (EPM) impairment is a significant contributor to
chronic pain. Conditioned pain modulation (CPM) testing assesses EPM function …

Canine studies of spontaneous osteoarthritis (OA) pain add valuable data supporting drug
treatment mechanisms that may translate to humans. A multicenter, randomized, double …

Osteoarthritis (OA)-associated pain is a leading cause of disability. Central sensitization
(CS), as a result of OA, is recognized as an important facet of human patients' chronic pain …

Background and purpose The use of laboratory animals in pain research has powerfully
contributed to our detailed understanding of the physiological mechanisms of pain. Animal …

In man, central sensitisation (CS) contributes to the pain of osteoarthritis (OA). Dogs with
spontaneous OA may also exhibit CS. Electrophysiological reflex measurements are more …

In cats, osteoarthritis causes significant chronic pain. Chronicity of pain is associated with
changes in the central nervous system related to central sensitization, which have to be …

Background The conceptual validity of kinetic gait analysis and disability outcome
assessment methods has guided their use in the assessment of pain caused by …

Objective Reporting the rate of positive (+) and negative (–) responders based on an
objective outcome measure of pain-related functional disability/lameness in dogs with …

This study aimed to characterize osteoarthritis (OA)-related chronic pain and disability in
experimental cats with naturally occurring OA. Peak vertical ground reaction force (PVF) …

The lack of successful translation of basic research discoveries into safe and effective
treatments for chronic pain patients has led to increased scrutiny of the preclinical models …