Developing novel treatments for HTLV-1-associated myelopathy (HAM) by investigating molecular pathomechanisms.
N Araya, T Sato, A Coler-Reilly, N Yagishita… - Nihon Rinsho Men'eki …, 2016 - europepmc.org
A small percentage of those infected with human T-lymphotropic virus type 1 (HTLV-1)
develop HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a …
develop HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a …
[HTML][HTML] In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy …
M Saito, T Matsuzaki, Y Satou, J Yasunaga, K Saito… - Retrovirology, 2009 - Springer
Background Recently, human T-cell leukemia virus type 1 (HTLV-1) basic leucine zipper
factor (HBZ), encoded from a minus strand mRNA was discovered and was suggested to …
factor (HBZ), encoded from a minus strand mRNA was discovered and was suggested to …
IFN‐γ production in response to Tax 161–233, and frequency of CD4+ Foxp3+ and Lin− HLA‐DRhigh CD123+ cells, discriminate HAM/TSP patients from …
I Best, G López, K Verdonck, E González… - …, 2009 - Wiley Online Library
Human T‐lymphotropic virus 1 (HTLV‐1) can cause HTLV‐1‐associated myelopathy/tropical
spastic paraparesis (HAM/TSP). The objective of this study was to gain insight into the …
spastic paraparesis (HAM/TSP). The objective of this study was to gain insight into the …
Visualization of HTLV-1–specific cytotoxic T lymphocytes in the spinal cords of patients with HTLV-1–associated myelopathy/tropical spastic Paraparesis
E Matsuura, R Kubota, Y Tanaka… - … of Neuropathology & …, 2015 - academic.oup.com
Activated human T-lymphotropic virus type-1 (HTLV-1)–specific CD8-positive cytotoxic T
lymphocytes (CTLs) are markedly increased in the periphery of patients with HTLV-1 …
lymphocytes (CTLs) are markedly increased in the periphery of patients with HTLV-1 …
Reduced Foxp3 expression with increased cytomegalovirus-specific CTL in HTLV-I-associated myelopathy
D Hayashi, R Kubota, N Takenouchi, Y Tanaka… - Journal of …, 2008 - Elsevier
Human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic
paraparesis (HAM/TSP) patients show high immune responses to HTLV-I. However, it is …
paraparesis (HAM/TSP) patients show high immune responses to HTLV-I. However, it is …
High IFN-γ/IL-10 expression ratio and increased frequency of persistent human T-cell lymphotropic virus type 1-infected clones are associated with human T-cell …
OM Espíndola, LC Oliveira, P Ferreira, ACCB Leite… - Intervirology, 2015 - karger.com
Background/Aims: Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that
causes a persistent infection, and only 0.5-5% of infected individuals will develop HTLV-1 …
causes a persistent infection, and only 0.5-5% of infected individuals will develop HTLV-1 …
[HTML][HTML] Minocycline modulates antigen-specific CTL activity through inactivation of mononuclear phagocytes in patients with HTLV-I associated neurologic disease
Y Enose-Akahata, E Matsuura, Y Tanaka, U Oh… - Retrovirology, 2012 - Springer
Background The activation of mononuclear phagocytes (MPs), including monocytes,
macrophages and dendritic cells, contributes to central nervous system inflammation in …
macrophages and dendritic cells, contributes to central nervous system inflammation in …
Blockade of IL-2 receptor suppresses HTLV-I and IFN-γ expression in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis
N Fukushima, Y Nishiura, T Nakamura, S Kohno… - Internal …, 2007 - jstage.jst.go.jp
Objective: Th1 activation based on a high HTLV-I proviral load is one of the characteristic
immunological abnormalities in the peripheral blood lymphocytes of patients with HTLV-I …
immunological abnormalities in the peripheral blood lymphocytes of patients with HTLV-I …
[HTML][HTML] Immunovirological markers in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Y Enose-Akahata, S Jacobson - Retrovirology, 2019 - Springer
Human T cell lymphotropic virus 1 (HTLV-1) is a human retrovirus and infects approximately
10–20 million people worldwide. While the majority of infected people are asymptomatic …
10–20 million people worldwide. While the majority of infected people are asymptomatic …
[HTML][HTML] Cytokine profile and proviral load among Japanese immigrants and non-Japanese infected with HTLV-1 in a non-endemic area of Brazil
JA Domingos, LS Soares, LM Bandeira, CM Bonin… - PLoS …, 2017 - journals.plos.org
The lifetime risk of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)
development differs among ethnic groups. To better understand these differences, this …
development differs among ethnic groups. To better understand these differences, this …