Exchange transfusion of large volumes of hemoglobin (Hb)-based oxygen carriers can
protect the brain from middle cerebral artery occlusion (MCAO). Hb in the carboxy state …

841, 2002. First published November 8, 2001; 10.1152/ajpheart. 00880.2001.—The
beneficial effect of hemodilution on cerebral blood flow (CBF) during focal cerebral ischemia …

The effect of transfusion of PEGylated hemoglobin (PEG-Hb) was evaluated in anesthetized
rats subjected to 2 hours of focal cerebral ischemia and 1 day of reperfusion. PEG-Hb was …

Cell-free hemoglobin solutions with high oxygen affinity might be beneficial for selectively
delivering oxygen to ischemic tissue. A recombinant hybrid hemoglobin molecule was …

Hemodilution has had limited success as a treatment of cerebral ischemia. When using a
nonoxygen binding fluid, the therapeutic efficacy of hemodilution-induced increases in CBF …

In a rat model of middle cerebral artery occlusion (MCAo) and reperfusion (120 min),
previous studies have demonstrated that hemodilution with molecular hemoglobin …

The application of hemoglobin (Hb)-based oxygen carriers (HBOCs) to the treatment of
cerebral ischemia has been investigated. A cluster of 1 Hb and 3 human serum albumins …

Background and Purpose—Transfusion of large polymers of hemoglobin avoids the
peripheral extravasation and hypertension associated with crosslinked tetrameric …

Glutaraldehyde-polymerized porcine hemoglobin (pPolyHb) is a hemoglobin-based oxygen
carrier currently being developed as a potential red blood cell substitute. We assessed the …

Background and Purpose—A hemoglobin-albumin cluster, 1 core of hemoglobin covalently
bound with 3 shell albumins, designated as HemoAct was developed as a hemoglobin …