Peptide nucleic acid (PNA) is a synthetic DNA analogue that is resistant to nucleases and
proteases and binds with exceptional affinity to RNA. Because of these properties PNA has …

Philadelphia-chromosome positive chronic myeloid leukemia cells in chronic phase (CML-
CP) or blast crisis (CML-BC) and normal bone marrow cells (NBMC) were incubated in vitro …

We have examined the effects of antisense oligomers (AOs) of various lengths, sequences
and chemistry on the proliferation of eight different cell lines, five derived from patients with …

When injected into SCID mice, the Philadelphia chromosome-positive chronic myeloid
leukemia-blast crisis cell line BV173 induces a disease process closely resembling that …

We have examined the effect of BCR/ABL junctional antisense phosphodiester
oligodeoxyribonucleotides (ODNs) on BV173 and other chronic myeloid leukemia (CML) …

Aberrant gene expression is characteristic to all cancer cells and pathophysiology in
general. Selective inhibition of constitutively elevated expression of oncogenes provides an …

Genome sequencing has revealed thousands of novel genes, placing renewed emphasis
on chemical approaches for controlling gene expression. Antisense oligomers designed …

Sequence specificity of inhibitory effects of various BCR‐ABL anti‐sense
oligodeoxynucleoside phosphorothioates (AS PS‐ODN) on the proliferation of the chronic …

Peptide nucleic acid (PNA) Is a DNA mimic with a pseudo-peptide backbone composed of
amlnoethyl glycine units. Several features of PNA, such as superior hybridization affinities to …

Peptide nucleic acids (PNAs) have shown great promise as potential antisense drugs;
however, poor cellular delivery limits their applications. Improved delivery into mammalian …