Unlike many cancers, the pattern of tumor evolution in papillary thyroid cancer (PTC) and its
potential role in relapse have not been elucidated. In this study, multi-region whole-exome …

Background: The need to integrate the classification of cancer with information on the
genetic pattern has emerged in recent years for several tumors. Methods: The genomic …

Purpose To evaluate the application of whole genome sequencing (WGS) in determining the
inter-foci clonal relationship of multifocal papillary thyroid carcinoma (mPTC). Methods After …

Improvement in the clinical outcome of human cancers requires characterization of the
genetic alterations underlying their pathogenesis. Large‐scale genomic and transcriptomic …

Papillary thyroid carcinoma (PTC) is frequently multifocal (mPTC), with synchronous tumour
foci often showing varied morphology. The genetic mechanisms underlying the development …

The contribution of intratumor heterogeneity to thyroid metastatic cancers is still unknown.
The clonal relationships between the primary thyroid tumors and lymph nodes (LN) or …

The incidence of papillary thyroid carcinomas (PTCs) has increased rapidly during the past
several decades. Until now, the mechanisms underlying the tumorigenesis of PTCs have …

Papillary thyroid carcinoma (PTC) is the most common adult thyroid malignancy and often
presents with multiple anatomically distinct foci within the thyroid, known as multifocal …

Background Understanding the molecular mechanisms underlying papillary thyroid cancer
(PTC) proved to be vital not only for diagnostic purposes but also for tailored treatments …

A landmark article by The Cancer Genome Atlas Research network describes the genetic
landscape of papillary thyroid carcinoma (PTC). This study identifies oncogenic driver …