Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci
N Zubair, M Graff, J Luis Ambite… - Human molecular …, 2016 - academic.oup.com
Genome-wide association studies have identified over 150 loci associated with lipid traits,
however, no large-scale studies exist for Hispanics and other minority populations …
however, no large-scale studies exist for Hispanics and other minority populations …
Transferability and fine mapping of genome-wide associated loci for lipids in African Americans
A Adeyemo, AR Bentley, KG Meilleur… - BMC medical …, 2012 - Springer
Background A recent, large genome-wide association study (GWAS) of European ancestry
individuals has identified multiple genetic variants influencing serum lipids. Studies of the …
individuals has identified multiple genetic variants influencing serum lipids. Studies of the …
Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained
Y Wu, LL Waite, AU Jackson, WHH Sheu… - PLoS …, 2013 - journals.plos.org
Genome-wide association studies (GWAS) have identified∼ 100 loci associated with blood
lipid levels, but much of the trait heritability remains unexplained, and at most loci the …
lipid levels, but much of the trait heritability remains unexplained, and at most loci the …
Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry
AB Kamiza, SM Touré, F Zhou, O Soremekun… - Nature …, 2023 - nature.com
Most genome-wide association studies (GWAS) for lipid traits focus on the separate analysis
of lipid traits. Moreover, there are limited GWASs evaluating the genetic variants associated …
of lipid traits. Moreover, there are limited GWASs evaluating the genetic variants associated …
Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations
CC Elbers, Y Guo, V Tragante, EPA van Iperen… - PloS one, 2012 - journals.plos.org
Meta-analyses of European populations has successfully identified genetic variants in over
100 loci associated with lipid levels, but our knowledge in other ethnicities remains limited …
100 loci associated with lipid levels, but our knowledge in other ethnicities remains limited …
Gene-based sequencing identifies lipid-influencing variants with ethnicity-specific effects in African Americans
AR Bentley, G Chen, D Shriner, AP Doumatey… - PLoS …, 2014 - journals.plos.org
Although a considerable proportion of serum lipids loci identified in European ancestry
individuals (EA) replicate in African Americans (AA), interethnic differences in the distribution …
individuals (EA) replicate in African Americans (AA), interethnic differences in the distribution …
Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations
Blood lipid concentrations are heritable risk factors associated with atherosclerosis and
cardiovascular diseases. Lipid traits exhibit considerable variation among populations of …
cardiovascular diseases. Lipid traits exhibit considerable variation among populations of …
Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study
ME Keebler, RC Deo, A Surti… - Circulation …, 2010 - Am Heart Assoc
Background—Genome-wide association studies in cohorts of European descent have
identified novel genomic regions as associated with lipids, but their relevance in African …
identified novel genomic regions as associated with lipids, but their relevance in African …
Genetic architecture of lipid traits in the Hispanic community health study/study of Latinos
Background Despite ethnic disparities in lipid profiles, there are few genome-wide
association studies investigating genetic variation of lipids in non-European ancestry …
association studies investigating genetic variation of lipids in non-European ancestry …
Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project
K Musunuru, SPR Romaine, G Lettre, JG Wilson… - PloS one, 2012 - journals.plos.org
Background Whereas it is well established that plasma lipid levels have substantial
heritability within populations, it remains unclear how many of the genetic determinants …
heritability within populations, it remains unclear how many of the genetic determinants …
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