Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci

N Zubair, M Graff, J Luis Ambite… - Human molecular …, 2016 - academic.oup.com
Genome-wide association studies have identified over 150 loci associated with lipid traits,
however, no large-scale studies exist for Hispanics and other minority populations …

Transferability and fine mapping of genome-wide associated loci for lipids in African Americans

A Adeyemo, AR Bentley, KG Meilleur… - BMC medical …, 2012 - Springer
Background A recent, large genome-wide association study (GWAS) of European ancestry
individuals has identified multiple genetic variants influencing serum lipids. Studies of the …

Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained

Y Wu, LL Waite, AU Jackson, WHH Sheu… - PLoS …, 2013 - journals.plos.org
Genome-wide association studies (GWAS) have identified∼ 100 loci associated with blood
lipid levels, but much of the trait heritability remains unexplained, and at most loci the …

Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry

AB Kamiza, SM Touré, F Zhou, O Soremekun… - Nature …, 2023 - nature.com
Most genome-wide association studies (GWAS) for lipid traits focus on the separate analysis
of lipid traits. Moreover, there are limited GWASs evaluating the genetic variants associated …

Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations

CC Elbers, Y Guo, V Tragante, EPA van Iperen… - PloS one, 2012 - journals.plos.org
Meta-analyses of European populations has successfully identified genetic variants in over
100 loci associated with lipid levels, but our knowledge in other ethnicities remains limited …

Gene-based sequencing identifies lipid-influencing variants with ethnicity-specific effects in African Americans

AR Bentley, G Chen, D Shriner, AP Doumatey… - PLoS …, 2014 - journals.plos.org
Although a considerable proportion of serum lipids loci identified in European ancestry
individuals (EA) replicate in African Americans (AA), interethnic differences in the distribution …

Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations

MA Coram, Q Duan, TJ Hoffmann, T Thornton… - The American Journal of …, 2013 - cell.com
Blood lipid concentrations are heritable risk factors associated with atherosclerosis and
cardiovascular diseases. Lipid traits exhibit considerable variation among populations of …

Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study

ME Keebler, RC Deo, A Surti… - Circulation …, 2010 - Am Heart Assoc
Background—Genome-wide association studies in cohorts of European descent have
identified novel genomic regions as associated with lipids, but their relevance in African …

Genetic architecture of lipid traits in the Hispanic community health study/study of Latinos

M Graff, LS Emery, AE Justice, E Parra… - Lipids in Health and …, 2017 - Springer
Background Despite ethnic disparities in lipid profiles, there are few genome-wide
association studies investigating genetic variation of lipids in non-European ancestry …

Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project

K Musunuru, SPR Romaine, G Lettre, JG Wilson… - PloS one, 2012 - journals.plos.org
Background Whereas it is well established that plasma lipid levels have substantial
heritability within populations, it remains unclear how many of the genetic determinants …