The retinoblastoma protein (pRB) is one of the best-studied tumour suppressor gene
products. Its loss during the genesis of many human tumours, its inactivation by several DNA …

Studies of the retinoblastoma gene (Rb) have shown that its protein product (pRb) acts to
restrict cell proliferation, inhibit apoptosis, and promote cell differentiation. The frequent …

The retinoblastoma tumor suppressor protein (pRB) can inhibit cell cycle progression and
promote differentiation. pRB interacts with a variety of transcription factors, including …

Loss of a functional retinoblastoma tumor suppressor gene product, pRB, is a key step in the
development of many human tumors. pRB is a negative regulator of cell proliferation and …

The retinoblastoma protein (pRB) can both positively and negatively regulate transcription.
The former correlates with its ability to promote differentiation and the latter with its ability to …

The retinoblastoma gene (RB-1) was originally identified as the gene involved in hereditary
retinoblastoma. However, RB-1 mutations are found in a number of common mesenchymal …

Genetic evidence from retinoblastoma patients and experiments describing the mechanism
of cellular transformation by the DNA tumor viruses have defined a central role for the …

Rb was the first tumour suppressor identified through human genetic studies. The most
significant achievement after almost twenty years since its cloning is the revelation that Rb …

The retinoblastoma gene product, pRB, regulates cell proliferation by binding to and
inhibiting the activity of key growth promoting proteins. Several cellular proteins have been …

Biochemical analysis of the retinoblastoma protein's function has received considerable
attention since it was cloned just over 20 years ago. During this time pRB has emerged as a …