[HTML][HTML] D-enantiomeric peptides that eradicate wild-type and multidrug-resistant biofilms and protect against lethal Pseudomonas aeruginosa infections
C De La Fuente-Núñez, F Reffuveille, SC Mansour… - Chemistry & biology, 2015 - cell.com
In many infections, bacteria form surface-associated communities known as biofilms that are
substantially more resistant to antibiotics than their planktonic counterparts. Based on the …
substantially more resistant to antibiotics than their planktonic counterparts. Based on the …
[HTML][HTML] Synthetic antibiofilm peptides
C De La Fuente-Núñez, MH Cardoso… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Bacteria predominantly exist as multicellular aggregates known as biofilms that are
associated with at least two thirds of all infections and exhibit increased adaptive resistance …
associated with at least two thirds of all infections and exhibit increased adaptive resistance …
Anti-biofilm peptides as a new weapon in antimicrobial warfare
D Pletzer, SR Coleman, REW Hancock - Current opinion in microbiology, 2016 - Elsevier
Highlights•To date no antibiotics have been specifically developed for biofilm infections.•Anti-
biofilm peptides directly address chronic multi-resistant bacterial infections.•They …
biofilm peptides directly address chronic multi-resistant bacterial infections.•They …
[HTML][HTML] Critical assessment of methods to quantify biofilm growth and evaluate antibiofilm activity of host defence peptides
Biofilms are multicellular communities of bacteria that can adhere to virtually any surface.
Bacterial biofilms are clinically relevant, as they are responsible for up to two-thirds of …
Bacterial biofilms are clinically relevant, as they are responsible for up to two-thirds of …
[HTML][HTML] Broad-spectrum anti-biofilm peptide that targets a cellular stress response
C De la Fuente-Núñez, F Reffuveille, EF Haney… - PLoS …, 2014 - journals.plos.org
Bacteria form multicellular communities known as biofilms that cause two thirds of all
infections and demonstrate a 10 to 1000 fold increase in adaptive resistance to conventional …
infections and demonstrate a 10 to 1000 fold increase in adaptive resistance to conventional …
Antibiofilm activity of host defence peptides: complexity provides opportunities
Host defence peptides (HDPs) are integral components of innate immunity across all living
organisms. These peptides can exert direct antibacterial effects, targeting planktonic cells …
organisms. These peptides can exert direct antibacterial effects, targeting planktonic cells …
Antibiofilm peptides: potential as broad-spectrum agents
D Pletzer, REW Hancock - Journal of bacteriology, 2016 - Am Soc Microbiol
The treatment of bacterial diseases is facing twin threats, with increasing bacterial antibiotic
resistance and relatively few novel compounds or strategies under development or entering …
resistance and relatively few novel compounds or strategies under development or entering …
A broad-spectrum antibiofilm peptide enhances antibiotic action against bacterial biofilms
F Reffuveille, C De La Fuente-Nú̃nez… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Biofilm-related infections account for at least 65% of all human infections, but there are no
available antimicrobials that specifically target biofilms. Their elimination by available …
available antimicrobials that specifically target biofilms. Their elimination by available …
[HTML][HTML] Antimicrobial and antibiofilm peptides
A Di Somma, A Moretta, C Canè, A Cirillo, A Duilio - Biomolecules, 2020 - mdpi.com
The increasing onset of multidrug-resistant bacteria has propelled microbiology research
towards antimicrobial peptides as new possible antibiotics from natural sources …
towards antimicrobial peptides as new possible antibiotics from natural sources …
[HTML][HTML] Cationic amphipathic peptides KT2 and RT2 are taken up into bacterial cells and kill planktonic and biofilm bacteria
T Anunthawan, C De La Fuente-Núñez… - … et Biophysica Acta (BBA …, 2015 - Elsevier
We investigated the mechanisms of two tryptophan-rich antibacterial peptides (KT2 and
RT2) obtained in a previous optimization screen for increased killing of both Gram-negative …
RT2) obtained in a previous optimization screen for increased killing of both Gram-negative …