Background Results from previous studies suggested that a blunted response of renal
plasma flow (RPF) to angiotensin II infusion during a high-sodium diet (a phenotype …

A subset of essential hypertensives sensitive to salt and having normal or high renin levels
are termed nonmodulators. These subjects fail to modulate their renal blood flow and …

Effects of gender and genotype on the phenotypic expression of nonmodulating essential
hypertension. Nonmodulation describes a subset of the normal/high renin essential …

Objective In essential hypertensive patients, blunted renal plasma flow responsiveness to
angiotensin II suggests a pathologic increase in angiotensin II in the kidneys. This blunting …

Normotensive young men (mean age 36 years) with positive (PFH)(n= 13) and negative (n=
29) family histories of hypertension were investigated in order to study systemic and renal …

Essential hypertension has a familial predisposition, but the phenotype of elevated blood
pressure has delayed penetrance. Because the kidney is a crucial determinant of blood …

Objective An increased sensitivity to angiotensin II (Ang II) has been observed in patients
with established hypertension. In the current study we tested whether young normotensive …

The aim of this work was to ascertain, in nonmodulating essential hypertension, whether the
abnormality in the renal blood supply is extended to the extremities and showed a similar …

Aim: Young individuals genetically predisposed for essential hypertension have increased
renal vascular resistance. We evaluated whether 1 year of angiotensin II receptor blockade …

Objective Recently, we reported evidence for genetic linkage between human essential
hypertension and the angiotensinogen gene (AGT) and an association with a common …