Cationic, anionic, zwitterionic and, partially polar metabolites are very important constituents
of blood serum. Several of these metabolites underpin the core metabolism of cells (eg …

Polar hydrophilic metabolites have been identified as important actors in many biochemical
pathways. Despite continuous improvement and refinement of hydrophilic interaction liquid …

The analysis of polar metabolites based on liquid chromatography-mass spectrometry (LC-
MS) methods should take into consideration the complexity of interactions in LC columns to …

Metabolomics studies rely on the availability of suitable analytical platforms to determine a
vast collection of chemically diverse metabolites in complex biospecimens. Liquid …

Highly polar and ionic metabolites, such as sugars, most amino acids, organic acids or
nucleotides are not retained by conventional reversed-phase LC columns and polar …

Metabolomics is a new approach that is based on the systematic study of the full
complement of metabolites in a biological sample. Metabolomics has the potential to …

In the present work two different approaches, a semi-quantitative and a Derringer function
approach, were developed to assist column selection for method development in targeted …

Untargeted metabolomics of human plasma with mass spectrometry is of particular interest
in medical research to explore pathophysiology, find disease biomarkers or for the …

The efficient analysis of polar and charged metabolites in biological samples remains a
huge challenge in the field of metabolomics. Over the past years, novel mass spectrometry …

Profiling of body fluids is crucial for monitoring and discovering metabolic markers of health
and disease and for providing insights into human physiology. Since human urine and …