The synthesis of levetiracetam and its enantiomer by deracemization of (±)-2-bromobutyric
acid using either (S)-or (R)-N-phenylpantolactam as chiral auxiliaries, followed by SN2 …

An alternate synthesis of enantiomerically pure levetiracetam (Keppra®) - ScienceDirect Skip
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Total synthesis of levetiracetam, an active ingredient of epilepsy treatment medications, is
reported. The reported method is based on a one-pot dehydration/sigmatropic …

Levetiracetam,[(S)-1](Keppra®, 38), was approved by the FDA, at the end of 1999 as an
antiepileptic drug for an add-on therapy for partial onset seizures in adults with epilepsy …

A simple route to enantiomerically pure (S)-2-aminobutyramide–the chiral component of the
anti-epileptic drugs Levetiracetam and Brivaracetam has been developed. This approach is …

A short enantioselective synthesis of the antiepileptic agent, levetiracetam based on proline-catalyzed
asymmetric α-aminooxylation - ScienceDirect Skip to main contentSkip to article Elsevier …

We have developed an asymmetric total synthesis of nebracetam 3 by a chemoenzymatic
strategy. Diastereoselective Michael addition of nitromethane to the chiral lactam (S)-9d (> …

A gas chromatographic–mass spectrometric method was developed for the enantioselective
analysis of levetiracetam and its enantiomer (R)-α-ethyl-2-oxo-pyrrolidine acetamide in dog …

An asymmetric synthesis of the 3, 4-trans-disubstituted piperidine derivative (+)-paroxetine
from the chiral non racemic lactam 1 is reported. The p-fluorophenyl substituent is …

The asymmetric synthesis of Escitalopram has been completed using a lithiation–borylation
reaction as the key step. Suitably functionalized enantioenriched carbamate (er 98: 2) and …