Transgenic animals are important components of modern biomedical and veterinary
sciences. They produce recombinant proteins, enzymes and antibodies for treating diseases …

Genome editing in pigs has tremendous practical applications for biomedicine. The advent
of genome editing technology, with its use of site‐specific nucleases—including ZFNs …

Background Genome editing has been considered as powerful tool in agricultural fields.
However, genome editing progress in cattle has not been fast as in other mammal species …

Precise genome editing of large animals applied to livestock and biomedicine is nowadays
possible since the CRISPR revolution. This review summarizes the latest advances and the …

Abstract Background: The porcine species (Sus scrofa domesticus) has had a great impact
as a source of food worldwide, but also it is a very useful animal for biomedical applications …

Genetically modified pigs have been considered favorable resources in xenotransplantation.
Microinjection of randomly integrating transgenes into zygotes, somatic cell nuclear transfer …

Abstract Genome/gene-editing (GE) techniques, characterized by a low technological
barrier, high efficiency, and broad application among organisms, are now being employed …

Genetic modification enables modification of target genes or genome structure in livestock
and experimental animals. These technologies have not only advanced bioscience but also …

Dear Editor, Type1diabetes (T1D) is a lifelong (chronic) disease and a major health problem
throughout the world. This disease can be treated by either insulin injection or islet …

Pigs have anatomical, physiological and genomic characteristics that make them highly
suitable for modeling human diseases. Genetically modified (GM) pig models of human …