Novel 4-arylaminoquinazoline derivatives with (E)-propen-1-yl moiety as potent EGFR inhibitors with enhanced antiproliferative activities against tumor cells
L Chen, Y Zhang, J Liu, W Wang, X Li, L Zhao… - European Journal of …, 2017 - Elsevier
A series of novel 4-anilinoquinazoline derivatives with (E)-propen-1-yl moiety were
designed, synthesized and evaluated for biological activities in vitro. Most compounds …
designed, synthesized and evaluated for biological activities in vitro. Most compounds …
Novel 4-anilinoquinazoline derivatives featuring an 1-adamantyl moiety as potent EGFR inhibitors with enhanced activity against NSCLC cell lines
With the aim of overcoming gefitinib resistance, a series of novel quinazoline derivatives
bearing an adamantyl group on the aniline ring were synthesized as potent epidermal …
bearing an adamantyl group on the aniline ring were synthesized as potent epidermal …
Development of penipanoid C-inspired 2-benzoyl-1-methyl-2, 3-dihydroquinazolin-4 (1H)-one derivatives as potential EGFR inhibitors: synthesis, anticancer …
A novel class of penipanoid C-inspired 2-benzoyl-1-methyl-2, 3-dihydroquinazolin-4 (1H)-
ones (3a-3f) and 1-methyl-2-(3, 4, 5-trihydroxybenzoyl)-2, 3-dihydroquinazolin-4 (1H)-one …
ones (3a-3f) and 1-methyl-2-(3, 4, 5-trihydroxybenzoyl)-2, 3-dihydroquinazolin-4 (1H)-one …
Novel Pyrazoloquinolin-2-ones: Design, synthesis, docking studies, and biological evaluation as antiproliferative EGFR-TK inhibitors
Two new series of diethyl 2-[2-(substituted-2-oxo-1, 2-dihydroquinolin-4-yl) hydrazono]-
succinates 6a-g and 1-(2-oxo-1, 2-dihydroquinolin-4-yl)-1H-pyrazoles 7a-f have been …
succinates 6a-g and 1-(2-oxo-1, 2-dihydroquinolin-4-yl)-1H-pyrazoles 7a-f have been …
Development of a series of novel 4-anlinoquinazoline derivatives possessing quinazoline skeleton: Design, synthesis, EGFR kinase inhibitory efficacy, and evaluation …
J Chang, H Ren, M Zhao, Y Chong, W Zhao… - European Journal of …, 2017 - Elsevier
anilinoquinazoline-based derivatives represent an attractive scaffold for small molecular
EGFR-TKIs in the field of medicinal chemistry. A series of novel heterocyclic substituted …
EGFR-TKIs in the field of medicinal chemistry. A series of novel heterocyclic substituted …
Design and synthesis of 4, 6-substituted-(diaphenylamino) quinazolines as potent EGFR inhibitors with antitumor activity
HQ Li, DD Li, X Lu, YY Xu, HL Zhu - Bioorganic & medicinal chemistry, 2012 - Elsevier
A type of novel 4, 6-substituted-(diaphenylamino) quinazolines, which designed based on
the 4-(phenylamino) quinazoline moiety, have been discovered as potential EGFR …
the 4-(phenylamino) quinazoline moiety, have been discovered as potential EGFR …
Molecular design and synthesis of certain new quinoline derivatives having potential anticancer activity
DA Ibrahim, DA Abou El Ella, AM El-Motwally… - European Journal of …, 2015 - Elsevier
EGFR, which plays a vital role as a regulator of cell growth, is one of the intensely studied TK
targets of anticancer inhibitors. The most two common anticancer inhibitors are …
targets of anticancer inhibitors. The most two common anticancer inhibitors are …
Design, synthesis and in vitro antitumor activity of 4-aminoquinoline and 4-aminoquinazoline derivatives targeting EGFR tyrosine kinase
Two series of new 6-alkoxy-4-substituted-aminoquinazolines (2–4f) and their bioisoteric
quinoline congeners (5–7c) were designed and synthesized. Virtual screening was carried …
quinoline congeners (5–7c) were designed and synthesized. Virtual screening was carried …
6, 7-Dimorpholinoalkoxy quinazoline derivatives as potent EGFR inhibitors with enhanced antiproliferative activities against tumor cells
Y Zhang, L Chen, H Xu, X Li, L Zhao, W Wang… - European Journal of …, 2018 - Elsevier
Abstract A series of novel 6, 7-dimorpholinoalkoxy quinazoline derivatives was designed,
synthesized and evaluated as potent EGFR inhibitors. Most of synthesized derivatives …
synthesized and evaluated as potent EGFR inhibitors. Most of synthesized derivatives …
Synthesis, EGFR-TK inhibition and anticancer activity of new quinoxaline derivatives
EA Ahmed, MFA Mohamed, A Omran… - Synthetic …, 2020 - Taylor & Francis
Abstract Ethyl 4-substituted-3-oxo-quinoxaline-2-carboxylates 3–5 were obtained via
alkylation of ethyl 3-oxo-3, 4-dihydroquinoxaline-2-carboxylate (1). Compound 1 was …
alkylation of ethyl 3-oxo-3, 4-dihydroquinoxaline-2-carboxylate (1). Compound 1 was …