In vitro and in silico evaluation of antiproliferative activity of new isoxazolidine derivatives targeting EGFR: design, synthesis, cell cycle analysis, and apoptotic …
A series of novel enantiopure isoxazolidine derivatives were synthesized and evaluated for
their anticancer activities against three human cancer cell lines such as human breast …
their anticancer activities against three human cancer cell lines such as human breast …
Metronidazole acid acyl sulfonamide: A novel class of anticancer agents and potential EGFR tyrosine kinase inhibitors
Y Luo, Y Li, KM Qiu, X Lu, J Fu, HL Zhu - Bioorganic & medicinal chemistry, 2011 - Elsevier
A series of novel metronidazole derivatives were recently reported as potent anticancer
agents targeting EGFR and HER-2 by our group [Qian, Y.; Zhang, HJ; Zhang, H.; Xu, C.; …
agents targeting EGFR and HER-2 by our group [Qian, Y.; Zhang, HJ; Zhang, H.; Xu, C.; …
Synthesis and in vitro biological evaluation of novel quinazoline derivatives
Y Zhang, Y Zhang, J Liu, L Chen, L Zhao, B Li… - Bioorganic & Medicinal …, 2017 - Elsevier
A series of novel 4-arylamino-6-(5-substituted furan-2-yl) quinazoline derivatives were
designed, synthesized and evaluated on biological activities in vitro. Compound 2a, 3a and …
designed, synthesized and evaluated on biological activities in vitro. Compound 2a, 3a and …
Design, synthesis and biological evaluation of sulfamoylphenyl-quinazoline derivatives as potential EGFR/CAIX dual inhibitors
B Zhang, Z Liu, S Xia, Q Liu, S Gou - European Journal of Medicinal …, 2021 - Elsevier
Multi-target, especially dual-target, drug design has become a popular research field for
cancer treatment. Development of small molecule dual-target inhibitors through …
cancer treatment. Development of small molecule dual-target inhibitors through …
Design and synthesis of quinazolinones as EGFR inhibitors to overcome EGFR resistance obstacle
The epidermal growth factor receptor (EGFR) T790M mutant is found in about 50% of
clinically acquired resistance to gefitinib among patients with non-small cell lung cancer …
clinically acquired resistance to gefitinib among patients with non-small cell lung cancer …
Design, synthesis, and docking studies of quinazoline analogues bearing aryl semicarbazone scaffolds as potent EGFR inhibitors
Two series of quinazoline derivatives bearing aryl semicarbazone scaffolds (9a–o and 10a–
o) were designed, synthesized and evaluated for the IC 50 values against four cancer cell …
o) were designed, synthesized and evaluated for the IC 50 values against four cancer cell …
Novel pyridine-thiazolidinone-triazole hybrid glycosides targeting EGFR and CDK-2: Design, synthesis, anticancer evaluation, and molecular docking simulation
AF Kassem, MA Omar, ES Nossier, HM Awad… - Journal of Molecular …, 2023 - Elsevier
The observed toxicity of newly designed anticancer drugs is considered as an impediment
challenging phenomenon of intense concern arising from diversity in drug targets and the …
challenging phenomenon of intense concern arising from diversity in drug targets and the …
Structure-based design, synthesis and antiproliferative action of new quinazoline-4-one/chalcone hybrids as EGFR inhibitors
A new series of quinazoline-4-one/chalcone hybrids, 7–26, was synthesized in this study as
EGFR inhibitors with antiproliferative activity. Target compounds were synthesized and in …
EGFR inhibitors with antiproliferative activity. Target compounds were synthesized and in …
Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFR WT and EGFR T790M
A new series of pyrimidine-5-carbonitrile derivatives has been designed as ATP mimicking
tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR). These compounds …
tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR). These compounds …
Discovery of new [1, 4] dioxino [2, 3-f] quinazoline-based inhibitors of EGFR including the T790M/L858R mutant
X Qin, Z Li, L Yang, P Liu, L Hu, C Zeng… - Bioorganic & Medicinal …, 2016 - Elsevier
Abstract A novel series of 2, 3-dihydro-[1, 4] dioxino [2, 3-f] quinazoline derivatives were
designed, synthesized and evaluated as reversible and noncovalent epidermal growth …
designed, synthesized and evaluated as reversible and noncovalent epidermal growth …