A series of 30 non-covalent imidazo [1, 2-a] quinoxaline-based inhibitors of epidermal
growth factor receptor (EGFR) were designed and synthesized. EGFR inhibitory assessment …

This study represents the synthetic approaches of a new set of 2-(((3-(benzofuran-2-yl)-1-
phenyl-1H-pyrazol-4-yl) methylene) hydrazono)-5-(aryl) thiazolidin-4-one derivatives 4–22 …

In present study, we described the synthesis and biological evaluation of a new class of
EGFR inhibitors containing 2, 9-disubstituted 8-phenylthio/phenylsulfinyl-9 H-purine …

Abstract New series of 5-(morpholinosulfonyl) isatin derivatives were designed and
synthesized. The new compounds were characterized on the basis of spectral and …

As regards to the structural analysis and optimization of diverse potential EGFR inhibitors,
two series of imidazolyl-2-cyanoprop-2-enimidothioates and ethyl …

In the current investigation, a new class of quinazolinone N-acetohydrazides 9a-v was
designed as type II multi-kinase inhibitors. The target quinazolinones were tailored so that …

New benzothiazole-based derivatives were synthesized in the present work with the aim of
evaluating their antitumor activity. They were in vitro tested against hepatocellular carcinoma …

Abstract derivatives of benzo [g] indazole 5a, b, benzo [h] quinazoline 7, 12a-c, 13a-c and
15a-c and benzo [h] quinoline 17a-c and 19a-c were synthesized from 6-methoxy-3, 4 …

Adenosine triphosphate (ATP)-competitive inhibitors of the epidermal growth factor receptor
(EGFR) have provided a significant improvement in the disease outcome of nonsmall cell …

On the basis of combination strategy, a novel series of EGFR inhibitors were designed and
synthesized by combination of dithiocarbamic acid esters and 4-anilinoquinazolines. The …