This study was designed to investigate the antinociceptive activity of capsaicin in acute and
persistent nocifensor behavioural models and to determine whether this was mediated via a …

1 Capsazepine has recently been described as a competitive capsaicin antagonist. We have
used this compound to test the hypotheses that the in vitro and in vivo effects of capsaicin …

Capsaicin activates poorly myelinated primary afferent neurons, many of which are
polymodal nociceptors. Activation is accompanied by membrane depolarization and the …

Capsaicin was tested on peripheral fibres in vitro to determine whether evoked
depolarization or desensitization were likely to explain the antinociception observed after …

Capsaicin produces pain by selectively activating polymodal nociceptive neurons. This
involves a membrane depolarization and the opening of a unique, cation-selective, ion …

1 Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, capsaicin. The
present study shows the capsazepine acts as a competitive antagonist of capsaicin. 2 …

Intraplantar injection of capsaicin (1.6 μg/paw) into the mouse hindpaw produced an acute
paw-licking/biting response. This study was designed (1) to investigate the antinociceptive …

The antinociceptive effect of capsaicin to noxious chemical stimuli has been invariably
verified. As to thermal or mechanical nociception, however, routine pharmacological …

In previous publications we have already reported on the peculiar pharmacological effect of
capsaicin on sensory reception.""" It is well known that capsaicin, the pungent principle in …

The present study was undertaken to characterize spontaneous (ie, nonevoked) pain
behaviors (flinching, biting/licking) produced by local injections of capsaicin into the rat …