Human microglia show unique transcriptional changes in Alzheimer's disease
Microglia, the innate immune cells of the brain, influence Alzheimer's disease (AD)
progression and are potential therapeutic targets. However, microglia exhibit diverse …
progression and are potential therapeutic targets. However, microglia exhibit diverse …
[HTML][HTML] Alzheimer's patient microglia exhibit enhanced aging and unique transcriptional activation
K Srinivasan, BA Friedman, A Etxeberria, MA Huntley… - Cell reports, 2020 - cell.com
Damage-associated microglia (DAM) profiles observed in Alzheimer's disease (AD)-related
mouse models reflect an activation state that could modulate AD risk or progression. To …
mouse models reflect an activation state that could modulate AD risk or progression. To …
Microglia in Alzheimer's disease at single-cell level. Are there common patterns in humans and mice?
Alzheimer's disease (AD) is characterized by extracellular aggregates of amyloid β peptides,
intraneuronal tau aggregates, and neuronal death. This pathology triggers activation of …
intraneuronal tau aggregates, and neuronal death. This pathology triggers activation of …
The transcriptional landscape of microglial genes in aging and neurodegenerative disease
LW Bonham, DW Sirkis, JS Yokoyama - Frontiers in immunology, 2019 - frontiersin.org
Microglia, the brain-resident myeloid cells, are strongly implicated in Alzheimer's disease
(AD) pathogenesis by human genetics. However, the mechanisms by which microglial gene …
(AD) pathogenesis by human genetics. However, the mechanisms by which microglial gene …
Transcriptomic analysis of purified human cortical microglia reveals age-associated changes
Microglia are essential for CNS homeostasis and innate neuroimmune function, and play
important roles in neurodegeneration and brain aging. Here we present gene expression …
important roles in neurodegeneration and brain aging. Here we present gene expression …
Diverse brain myeloid expression profiles reveal distinct microglial activation states and aspects of Alzheimer's disease not evident in mouse models
BA Friedman, K Srinivasan, G Ayalon, WJ Meilandt… - Cell reports, 2018 - cell.com
Microglia, the CNS-resident immune cells, play important roles in disease, but the spectrum
of their possible activation states is not well understood. We derived co-regulated gene …
of their possible activation states is not well understood. We derived co-regulated gene …
Human microglial state dynamics in Alzheimer's disease progression
Altered microglial states affect neuroinflammation, neurodegeneration, and disease but
remain poorly understood. Here, we report 194,000 single-nucleus microglial transcriptomes …
remain poorly understood. Here, we report 194,000 single-nucleus microglial transcriptomes …
Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau
SS Kang, MTW Ebbert, KE Baker, C Cook… - Journal of Experimental …, 2018 - rupress.org
Alzheimer's disease (AD) is an age-associated neurodegenerative disease characterized by
amyloidosis, tauopathy, and activation of microglia, the brain resident innate immune cells …
amyloidosis, tauopathy, and activation of microglia, the brain resident innate immune cells …
Transcriptional and epigenetic decoding of the microglial aging process
As important immune cells, microglia undergo a series of alterations during aging that
increase the susceptibility to brain dysfunctions. However, the longitudinal characteristics of …
increase the susceptibility to brain dysfunctions. However, the longitudinal characteristics of …
Microglial brain region− dependent diversity and selective regional sensitivities to aging
Microglia have critical roles in neural development, homeostasis and neuroinflammation
and are increasingly implicated in age-related neurological dysfunction. Neurodegeneration …
and are increasingly implicated in age-related neurological dysfunction. Neurodegeneration …