Landscape of EGFR signaling network in human cancers: biology and therapeutic response in relation to receptor subcellular locations
W Han, HW Lo - Cancer letters, 2012 - Elsevier
The epidermal growth factor receptor (EGFR) pathway is one of the most dysregulated
molecular pathways in human cancers. Despite its well-established importance in tumor …
molecular pathways in human cancers. Despite its well-established importance in tumor …
The complexity of targeting EGFR signalling in cancer: from expression to turnover
S Sebastian, J Settleman, SJ Reshkin, A Azzariti… - … et Biophysica Acta (BBA …, 2006 - Elsevier
The epidermal growth factor receptor (ErbB1 or EGFR) has been found to be altered in a
variety of human cancers. A number of agents targeting these receptors, including specific …
variety of human cancers. A number of agents targeting these receptors, including specific …
EGFR signaling pathway as therapeutic target in human cancers
Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
Targeting the EGFR signaling pathway in cancer therapy
P Seshacharyulu, MP Ponnusamy… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: Cancer is a devastating disease; however, several therapeutic advances have
recently been made, wherein EGFR and its family members have emerged as useful …
recently been made, wherein EGFR and its family members have emerged as useful …
The EGFR family and its ligands in human cancer: signalling mechanisms and therapeutic opportunities
Y Yarden - European journal of cancer, 2001 - Elsevier
Growth factors and their transmembrane receptor tyrosine kinases play important roles in
cell proliferation, survival, migration and differentiation. One group of growth factors …
cell proliferation, survival, migration and differentiation. One group of growth factors …
Cellular responses to EGFR inhibitors and their relevance to cancer therapy
PR Dutta, A Maity - Cancer letters, 2007 - Elsevier
EGFR is a trans-membrane receptor tyrosine kinase that belongs to the HER family of
receptors. The EGFR family plays an essential role in normal organ development by …
receptors. The EGFR family plays an essential role in normal organ development by …
EGFR, HER2 and VEGF pathways: validated targets for cancer treatment
MF Press, HJ Lenz - Drugs, 2007 - Springer
Targeted therapies are rationally designed to interfere with specific molecular events that
are important in tumour growth, progression or survival. Several targeted therapies with anti …
are important in tumour growth, progression or survival. Several targeted therapies with anti …
Ligand-independent EGFR signaling
Constitutive activation of the EGFR is common in cancer due to EGFR wild-type (EGFRwt)
overexpression or the presence of mutant EGFR. Signaling by constitutively active NSCLC …
overexpression or the presence of mutant EGFR. Signaling by constitutively active NSCLC …
[HTML][HTML] EGFR in cancer: Signaling mechanisms, drugs, and acquired resistance
ML Uribe, I Marrocco, Y Yarden - Cancers, 2021 - mdpi.com
Simple Summary Growth factors are hormone-like molecules able to promote division and
migration of normal cells, but cancer captured the underlying mechanisms to unleash tumor …
migration of normal cells, but cancer captured the underlying mechanisms to unleash tumor …