Influenza A antigen exposure selects dominant Vβ17+ TCR in human CD8+ cytotoxic T cell responses
TM Lawson, S Man, S Williams… - International …, 2001 - academic.oup.com
During acute human viral infections, such as influenza A, specific cytotoxic T lymphocytes
(CTL) are generated which aid virus clearance. We have observed that in HLA-A* 0201+ …
(CTL) are generated which aid virus clearance. We have observed that in HLA-A* 0201+ …
Functional differences between influenza A-specific cytotoxic T lymphocyte clones expressing dominant and subdominant TCR
TM Lawson, S Man, ECY Wang… - International …, 2001 - academic.oup.com
We have shown that the dominance of CD8+ T cells expressing TCR Vβ17 in the adult HLA-
A* 0201-restricted influenza A/M158–66-specific response is acquired following first antigen …
A* 0201-restricted influenza A/M158–66-specific response is acquired following first antigen …
Human HLA-A0201-restricted cytotoxic T lymphocyte recognition of influenza A is dominated by T cells bearing the V beta 17 gene segment.
The major histocompatibility complex class I-restricted cytotoxic T lymphocyte (CTL)
response is important in the clearance of viral infections in humans. After influenza A …
response is important in the clearance of viral infections in humans. After influenza A …
In VivoLongitudinal Analysis of a Dominant TCR Repertoire Selected in Human Response to Influenza Virus
A Prevost-Blondel, R Lengagne, F Letourneur… - Virology, 1997 - Elsevier
Recent studies have demonstrated biased usage of TCR Vβ17 and a high degree of
diversity in Jβ usage within the influenza virus matrix epitope (M. 58-66)-specific CTL …
diversity in Jβ usage within the influenza virus matrix epitope (M. 58-66)-specific CTL …
Contemporary analysis of MHC-related immunodominance hierarchies in the CD8+ T cell response to influenza A viruses
GT Belz, PG Stevenson, PC Doherty - The Journal of Immunology, 2000 - journals.aai.org
Early studies of influenza virus-specific CD8+ T cell-mediated immunity indicated that the
level of CTL activity associated with H2D b is greatly diminished in mice that also express …
level of CTL activity associated with H2D b is greatly diminished in mice that also express …
Quantification of repertoire diversity of influenza-specific epitopes with predominant public or private TCR usage
K Kedzierska, EB Day, J Pi, SB Heard… - The Journal of …, 2006 - journals.aai.org
The H-2D b-restricted CD8 T cell immune response to influenza A is directed at two well-
described epitopes, nucleoprotein 366 (NP366) and acid polymerase 224 (PA224). The …
described epitopes, nucleoprotein 366 (NP366) and acid polymerase 224 (PA224). The …
Potential killers exposed: tracking endogenous influenza‐specific CD8+ T cells
R Keating, MY Morris, W Yue… - Immunology and cell …, 2018 - Wiley Online Library
Current influenza A virus (IAV) vaccines stimulate antibody responses that are directed
against variable regions of the virus, and are therefore ineffective against divergent strains …
against variable regions of the virus, and are therefore ineffective against divergent strains …
Narrowed TCR diversity for immunised mice challenged with recombinant influenza A-HIV Env311–320 virus
T Cukalac, JM Moffat, V Venturi, MP Davenport… - Vaccine, 2009 - Elsevier
Understanding CD8+ T cell responses generated by live virus vectors is critical for the
rational design of next generation HIV CTL-based vaccines. We used recombinant influenza …
rational design of next generation HIV CTL-based vaccines. We used recombinant influenza …
In vivo selection of a TCR Vβ repertoire directed against an immunodominant influenza virus CTL epitope
W Zhong, EL Reinherz - International immunology, 2004 - academic.oup.com
Little is known about the mechanisms governing TCR repertoire selection in response to
foreign antigens. Here, we evaluate the molecular features of the murine C57BL/6 (B6) TCR …
foreign antigens. Here, we evaluate the molecular features of the murine C57BL/6 (B6) TCR …
Precursor frequency and competition dictate the HLA-A2–restricted CD8+ T cell responses to influenza A infection and vaccination in HLA-A2. 1 transgenic mice
ACL Tan, NL La Gruta, W Zeng… - The Journal of …, 2011 - journals.aai.org
The human HLA-A2–restricted CD8+ T cell response to influenza A virus (IAV) is largely
directed against the matrix protein-derived M1 58–66 epitope and represents an archetypal …
directed against the matrix protein-derived M1 58–66 epitope and represents an archetypal …
相关搜索
- antigen exposure cell responses
- human cd8 cell responses
- human cd8 antigen exposure
- tcr repertoire human response
- influenza virus human response
- influenza virus tcr repertoire
- infection and vaccination cell responses
- hla a2 cell responses
- cell response immunodominance hierarchies
- precursor frequency cell responses
- transgenic mice cell responses
- restricted cd8 cell responses