The CD8+ T cell response to the immunodominant DbNP366 epitope has been analyzed
sequentially to determine the prevalence and persistence of different T cell antigen receptor …

Influenza is a contagious, acute respiratory disease that is a major cause of morbidity and
mortality throughout the world. CD4 T cells play an important role in the immune response to …

The spectrum of TCR usage has been analyzed for virus-specific CD8+ T cells isolated from
the regional mediastinal lymph modes and from the lung by bronchoalveolar lavage (BAL) of …

Although previous studies have found minimal changes in CD4 T cell responses after
vaccination of adults with trivalent inactivated influenza vaccine, daily sampling and …

Highlights•Humans have a diverse repertoire of circulating CD4 T cells specific for influenza
viral proteins.•Critical CD4 T cell functions include help for B cell and CD8 T cell responses …

Detailed assessment of how the structural properties of T cell receptors affect clonal
repertoires of Ag-specific cells is a prerequisite for a better understanding of human antiviral …

Respiratory challenge of H-2b mice with an H3N2 influenza A virus causes an acute,
transient pneumonitis characterized by the massive infiltration of CD8+ T lymphocytes. The …

Single-cell analysis of endogenous, primary CD8+ T cell responses to the influenza
DbNP366 and DbPA224 epitopes indicates that prominent clonotypes bearing “public” or …

The anti-influenza CD8+ T cell response in HLA-A2–positive adults is almost exclusively
directed at residues 58–66 of the virus matrix protein (MP (58–66)). Vβ17Vα10. 2 T cell …

Antigen expressed as MHC Class I glycoprotein (pMHCI) complexes on dendritic cells is the
primary driver of CD8+ T cell clonal expansion and differentiation. As we seek to define the …