TCR signal strength during priming is a key determinant of CD4 T cell activation, but its
impact on effector CD4 T functions in vivo remains unclear. In this study, we compare the …

CD8+ T cells recognizing antigenic peptides derived from conserved internal viral proteins
confer broad protection against distinct influenza viruses. As memory CD8+ T cells change …

Like αβ T cells, human γδ T cells also have different subsets with distinct characteristics.
Whether human Vγ9Vδ2 T cells have functionally different subsets in response to influenza …

Abstract Memory Thy-1+ CD8+ T cells specific for the influenza A virus nucleoprotein (NP
366–374) peptide were sorted after staining with the D b NP 366 tetramer, labeled with …

We combined several recent technological advances in immunology and molecular biology
to identify and sequence a large number of T-cell receptor (TCR) genes specific for a …

Cytokine production by memory T cells is a key mechanism of T cell mediated protection.
However, we have limited understanding of the persistence of cytokine producing T cells …

The effect of trivalent inactivated influenza vaccine (TIV) or live attenuated influenza vaccine
(LAIV) on the phenotypes of circulating influenza-specific CD8+ T cells was analyzed by …

The ability of influenza A virus-specific cytotoxic T lymphocytes (CTL) to degranulate and
produce cytokines upon antigenic restimulation was studied in four HLA-A* 0101 and HLA …

Recently, an avian influenza A virus (A/Hong Kong/156/97, H5N1) was isolated from a
young child who had a fatal influenza illness. All eight RNA segments were of avian origin …

TCR repertoire diversity can influence the efficacy of CD8+ T‐cell populations, with greater
breadth eliciting better protection. We analyzed TCRβ diversity and functional capacity for …