Context Purpose in life is associated with a substantially reduced risk of Alzheimer disease
(AD), but the neurobiologic basis of this protective effect remains unknown. Objective To test …

Context Emerging data suggest that psychological and experiential factors are associated
with risk of Alzheimer disease (AD), but the association of purpose in life with incident AD is …

Objective This study examined whether having a sense of purpose in life protects against
cognitive decline among older adults and whether purpose in life moderates the relationship …

With an increasingly aging population, more work is needed to identify factors which may
promote the maintenance of normal cognitive functioning. The current study tested the …

Background Purpose in life is thought to be associated with positive health outcomes in old
age, but its association with disability is unknown. Objective Test the hypothesis that greater …

It is increasingly recognized that the correlation between neuropathological lesions and
cognition is modest and accounts for about a quarter of the variance of cognition among …

Background: A sense of purpose in life has been associated with healthier cognitive
outcomes across adulthood, including risk of dementia. The robustness and replicability of …

Objective Well‐being is a psychological resource that buffers against age‐related disease.
We test whether this protective effect extends to dementia and whether it is independent of …

Importance A healthy lifestyle is associated with better cognitive functioning in older adults,
but whether this association is independent of the accumulation of dementia-related …

This study addressed the hypothesis that late life cognitive decline leads to loss of well-
being. Participants are older persons from the Rush Memory and Aging Project. Beginning …