Inactivation of retinoblastoma protein (Rb) plays a critical role in the development of human
malignancies. It has been shown that Rb is degraded through a proteasome-dependent …

Inactivation of retinoblastoma protein (Rb) plays a key role in human tumorigenesis.
Although the regulation of Rb by phosphorylation has been extensively studied, the …

Retinoblastoma gene product (pRB) plays critical roles in regulation of the cell cycle and
tumor suppression. It is known that downregulation of pRB can stimulate carcinogenesis via …

Retinoblastoma (Rb) protein is a paradigm of tumor suppressors. Inactivation of Rb plays a
critical role in the development of human malignancies. MDM2, an oncogene frequently …

The tumor suppressor protein p53 is negatively regulated by Mdm2, a ubiquitin ligase
protein that targets p53 for degradation. Mdmx (also known as Mdm4) is a relative of Mdm2 …

Retinoblastoma is a childhood cancer of the developing retina that begins in utero and is
diagnosed in the first years of life. Biallelic RB1 gene inactivation is the initiating genetic …

MDM2 is an oncogene that mainly functions to modulate p53 tumor suppressor activity. In
normal cells the MDM2 protein binds to the p53 protein and maintains p53 at low levels by …

Tumor suppressor p53 plays a central role in preventing tumor formation. The levels and
activity of p53 is under tight regulation to ensure its proper function. Murine double minute 2 …

The p53 tumor suppressor is regulated by MDM2-mediated ubiquitination and degradation.
Mitogenic signals activate p53 by induction of ARF expression, which inhibits p53 …

Mdm2 is best known as the primary negative regulator of p53, but a growing body of
evidence suggests that Mdm2 also has a number of functions independent of its role in …