Naive pluripotent embryonic stem cells (ESCs) and embryonic germ cells (EGCs) are
derived from the preimplantation epiblast and primordial germ cells (PGCs), respectively …

Epigenetic resetting in the mammalian germ line entails acute DNA demethylation, which
lays the foundation for gametogenesis, totipotency, and embryonic development. We …

Epigenetic reprogramming in the germline resets genomic potential and erases epigenetic
memory. Three studies by Gkountela et al., Guo et al., and Tang et al. analyze the …

Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …

The expansion of primordial germ cells (PGC s), the precursors for the oocytes and
spermatozoa, is a key challenge in reproductive biology/medicine. Using a chemical …

Embryonic (ES) and epiblast (EpiSC) stem cells are pluripotent but committed to an
embryonic lineage fate. Conversely, trophoblast (TS) and extraembryonic endoderm (XEN) …

In this review, advances in the understanding of epigenetic reprogramming from fertilization
to the development of primordial germline cells in a mouse and human embryo are …

Extensive epigenetic reprogramming occurs during preimplantation embryo development.
However, it remains largely unclear how the drastic epigenetic reprogramming contributes to …

Genome‐wide DNA demethylation, including the erasure of genome imprints, in primordial
germ cells (PGCs) is a critical first step to creating a totipotent epigenome in the germ line …

DNA methylation is dynamically remodelled during the mammalian life cycle through distinct
phases of reprogramming and de novo methylation. These events enable the acquisition of …