Epigenetic reprogramming of parental genomes following fertilization is important to ensure
compatibility for totipotency and development thereafter. New studies by Jiang et al. and …

Induction of mouse germ cells occurs from the proximal epiblast at around embryonic day
(E) 7.0. These germ cells then migrate to, and enter the gonads at about E10. 5 after which …

Genome-wide dynamic changes in DNA methylation are indispensable for germline
development and genomic imprinting in mammals. Here, we report single-base resolution …

In mammals, the canonical somatic DNA methylation landscape is established upon
specification of the embryo proper and subsequently disrupted within many cancer types …

Background Genomic methylation patterns are established during gametogenesis, and
perpetuated in somatic cells by faithful maintenance methylation. There have been previous …

Primordial germ cells (PGCs) and somatic cells originate from postimplantation epiblast cells
in mice. As pluripotency is lost upon differentiation of somatic lineages, a naive epigenome …

DNA methylation is a tightly regulated epigenetic mark associated with transcriptional
repression. Next-generation sequencing of purified methylated DNA obtained from early …

Background Previously, a role was demonstrated for transcription in the acquisition of DNA
methylation at imprinted control regions in oocytes. Definition of the oocyte DNA methylome …

In contrast to mouse, human female germ cells develop asynchronously. Germ cells
transition to meiosis, erase genomic imprints, and reactivate the X chromosome. It is …

Epigenetic reprogramming in the germline provides a developmental model to study the
erasure of epigenetic memory as it occurs naturally in vivo in the course of normal …