Global demethylation is part of a conserved program of epigenetic reprogramming to naive
pluripotency. The transition from primed hypermethylated embryonic stem cells (ESCs) to …

Mouse embryonic stem cells are dynamic and heterogeneous. For example, rare cells cycle
through a state characterized by decondensed chromatin and expression of transcripts …

Epigenetic alterations are increasingly recognized as causes of human cancers and
disease. These aberrations are likely to arise during genomic reprogramming in mammalian …

The generation of genome-wide data derived from methylated DNA immunoprecipitation
followed by sequencing (MeDIP-seq) has become a major tool for epigenetic studies in …

DNA methylation is extensively remodeled during mammalian gametogenesis and
embryogenesis. Most transposons become hypomethylated, raising the question of their …

In mammals, cytosine methylation is predominantly restricted to CpG dinucleotides and
stably distributed across the genome, with local, cell-type-specific regulation directed by …

DNA methylation is crucial for a wide variety of biological processes, yet no technique
suitable for the methylome analysis of DNA methylation at single-cell resolution is available …

There are distinctive and characteristic genomic modifications in primordial germ cells that
distinguish the germ cell lineage from somatic cells. These modifications include, genome …

The fate and function of epigenetic marks during the germline-to-embryo transition is a key
issue in developmental biology, with relevance to stem cell programming and …

Germ cells undergo comprehensive epigenetic reprogramming toward acquiring fitness for
pluripotency and totipotency. Notably, the full extent of the epigenetic reprogramming …