In vivo imaging of molecular events in small animals has great potential to impact basic
science and drug development. For this reason, several imaging technologies have been …

There is a wealth of new fluorescent reporter technologies for tagging of many cellular and
subcellular processes in vivo. This imposed contrast is now captured with an increasing …

Fluorescence microscopic imaging is widely used in biomedical research to study molecular
and cellular processes in cell culture or tissue samples. This is motivated by the high …

Fluorescence imaging is increasingly used to probe protein function and gene expression in
live animals. This technology could enhance the study of pathogenesis, drug development …

Optical imaging can advance knowledge of cellular biology and disease at the molecular
level in vitro and, more recently, in vivo. In vivo optical imaging has enabled real-time study …

In vivo fluorescence imaging uses a sensitive camera to detect fluorescence emission from
fluorophores in whole-body living small animals. To overcome the photon attenuation in …

Volumetric detection and accurate quantification of fluorescent proteins in entire animals
would greatly enhance our ability to monitor biological processes in vivo. Here we present a …

BACKGROUND Molecular imaging can be broadly de? ned as the charac teriZation and
measurement of biological processes at the cellular and molecular level in mammals and …

Methods that allow robust imaging of specific molecular targets and biological processes in
vivo should have widespread applications in biology and clinical medicine. Here we use a …

Fluorescence molecular tomography is an emerging imaging technique that resolves the bio-
distribution of engineered fluorescent probes developed for in vivo reporting of specific …